2-Chloro-5-nitroaniline

172.57

172.57

2208878

228-498-7

PO198891S5

7791

DTXSID6038827

Yellow needles from petroleum ether

2921420090

71.8

2.1

yellow powder

1.5±0.1 g/cm3

121 °C

314.6°C at 760 mmHg

191°C

1.646

In water, 933 mg/L at 25 deg C (est)

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Store away from oxidizing agents.

4.85X10-4 mm Hg at 25 deg C (est)

Oral-Rat  LD50: 2015 mg/kg; Oral-Mouse LD50: 1600 mg/kg

Combustible, decomposes toxic chloride, nitrogen oxide gas when burning

Henry's Law constant = 5.57X10-9 atm-cu m/mol at 25 °C (est)

Hydroxyl radical reaction rate constant = 2.75X10-12 cu cm/molec-sec at 25 °C (est)

III

6.1

UN 2237 6.1/PG 3

3

26/27/28-33-51/53-50/53

28-36/37-45-61-28A-60-13

BX1500000

T+,N

Warehouse low temperature, ventilated, dry

Stable under normal temperatures and pressures.

P260-P264-P273-P280-P284-P301 + P310

H300-H310-H330-H373-H411

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

|Danger|H300 (93.62%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P262, P264, P270, P271, P273, P280, P284, P301+P310, P302+P350, P304+P340, P310, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Personnel protection: ... Wear positive pressure self-contained breathing apparatus. ... Wear appropriate chemical protective clothing Do not handle broken packages unless wearing appropriate personal protective equipment.|Breathing equipment: Use suitable respirator when high concentrations are present. Protection of hands: Impervious gloves; check protective gloves prior to each use for their proper condition. ... Eye protection: Safety glasses. Body protection: Protective work clothing.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources.|Fire fighting measures. Suitable extinguishing agents. Carbon dioxide, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Special hazards caused by the material, its products of combustion or resulting gases: In case of fire, the following can be released: carbon monoxide and carbon dioxide, nitrogen oxides, hydrogen chloride. Protective equipment: Wear self-contained respirator. Wear fully protective impervious suit.

/Use in/ properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 ft per minute.|The usual precautionary measures for handling chemicals should be followed. Keep away from foodstuffs, beverages and feed. Remove all soiled and contaminated clothing immediately. Wash hands before breaks and at the end of work. Avoid contact with the eyes and skin.|In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.|Wear suitable protective clothing and gloves.|For more Preventive Measures (Complete) data for 2-CHLORO-5-NITROANILINE (7 total), please visit the HSDB record page.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Chloronitroanilines/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Chloronitroanilines/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Chloronitroanilines/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Chloronitroanilines/|For more DOT Emergency Guidelines (Complete) data for 2-CHLORO-5-NITROANILINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Irritating to eyes, respiratory system and skin.

moderately toxic

LD50 Rat oral 2015 mg/kg|LD50 Mice oral 1600 mg/kg

Routine checking of lips, tongue and nail beds of exposed personnel for signs of cyanosis. /Protect/ from exposure those individuals with anemia, cardiovascular or pulmonary diseases.

2-Chloro-5-nitroaniline's production and use as a chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 390(SRC), determined from a log Kow of 2.23(2) and a regression-derived equation(3), indicates that 2-chloro-5-nitroaniline is expected to have moderate mobility in soil(SRC). Volatilization of 2-chloro-5-nitroaniline from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.6X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(4). 2-Chloro-5-nitroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.8X10-4 mm Hg(SRC), determined from a fragment constant method(5). A biodegradation half-life of 9.9 hours determined using a bank infiltration simulation test(6) suggests that biodegradtion may be an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 390(SRC), determined from a log Kow of 2.23(2) and a regression-derived equation(3), indicates that 2-chloro-5-nitroaniline is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.6X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 10(SRC), from its log Kow of 2.23(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A biodegradation half-life of 9.9 hours determined using a bank infiltration simulation test(7) suggests that biodegradtion may be an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-chloro-5-nitroaniline, which has an estimated vapor pressure of 4.8X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-chloro-5-nitroaniline is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5.8 days(SRC), calculated from its rate constant of 2.7X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2-Chloro-5-nitroaniline contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 2-chloro-5-nitroaniline with photochemically-produced hydroxyl radicals has been estimated as 2.7X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5.8 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2-Chloro-5-nitroaniline is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 2-Chloro-5-nitroaniline contains chromophores that absorb at wavelengths >290 nm(2) and therefore may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 10 was calculated in fish for 2-chloro-5-nitroaniline(SRC), using a log Kow of 2.23(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 2-chloro-5-nitroaniline is estimated as 390(SRC), using a log Kow of 2.23(1) and a regression-derived equation(2). According to a classification scheme(3), this Koc value suggests that 2-chloro-5-nitroaniline is expected to have moderate mobility in soil. However, anilines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4,5), suggesting that mobility may be much lower in some soils(SRC). The log Koc of 2-chloro-5-nitroaniline was measured as 2.23 in Yangtze river sediment (37.1% sand, 49.3% silt, 13.6% clay, 1.28% organic carbon, pH 7.44)(1). The log Koc was also measured as 3.63 in modified clay(6). These values give Koc values of 170 and 4,300, respectively(SRC).

The Henry's Law constant for 2-chloro-5-nitroaniline is estimated as 5.6X10-9 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 2-chloro-5-nitroaniline is expected to be essentially nonvolatile from water surfaces(2). 2-Chloro-5-nitroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.8X10-4 mm Hg(SRC), determined from a fragment constant method(3).

Occupational exposure to 2-chloro-5-nitroaniline may occur through dermal contact with this compound at workplaces where 2-chloro-5-nitroaniline is produced or used. (SRC)

/SIGNS AND SYMPTOMS/ Harmful if swallowed. Irritating to eyes, respiratory system and skin.

Benzenamine, 2-chloro-5-nitro-: ACTIVE

Analyte: /p-Nitroaniline/; Matrix: Air; Procedure: Adsorption on silica gel, elution by ethanol, gas chromatography; Range: .01 - 14 mg/sample. Sampling interference: water vapor; Overall precision: +9 or -9. /p-Nitroaniline/