Pazopanib hydrochloride
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Pazopanib hydrochloride
structure -
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CAS No:
635702-64-6
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Formula:
C21H23N7O2S.ClH
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Chemical Name:
Pazopanib hydrochloride
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Synonyms:
Benzenesulfonamide,5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-,hydrochloride (1:1);Benzenesulfonamide,5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-,monohydrochloride;Pazopanib hydrochloride;GW 786034B;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide hydrochloride
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CAS No:
Description
Pazopanib Hydrochloride is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
Characteristics
127
5.79510
728.8ºC at 760 mmHg
394.6ºC
In water, 3.3 mg/L at 25 deg C (est)
Store at room temperature between 20 deg C and 25 deg C (68 deg F to 77 deg F); excursions permitted to 15 deg C to 30 deg C (59 deg F to 86 deg F).
3.21X10-14 mm Hg at 25 deg C (est)
Safety Information
Stable if stored as directed; avoid strong oxidizing agents. /Pazopanib hydrochloride/
P201, P202, P260, P264, P270, P273, P281, P308+P313, P314, P391, P405, P501
H361
Pazopanib hydrochloride Use and Manufacturing
Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively - See more at: http://www.selleckchem.com/products/Pazopanib-Hyd
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