Pazopanib HCl
2 Inquiries
635702-64-6
99%
2026-07-07
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Pazopanib HCl Cat No CEI-0009 Description Pazopanib (GW786034B; GlaxoSmithKline) is a novel multi-targeted, orally available, small-molecule tyrosine kinase inhibitor of VEGF receptor 1, VEGF receptor 2, and VEGF receptor 3 with IC50 values of 10, 30, and 47 nM. Alias GW786034 CAS No 635702-64-6 Molecular Weight 473.98 Purity >99% Storage 2 years at -20 centigrade Synonyms GW786034 Targets VEGFR1, VEGFR2, VEGFR3 Molecular Formula C21H23N7O2S.HCl Chemical Name 5-(4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide hydrochloride Solubility DSMO 70 mg/mL Water 17 mg/mL Ethanol In vitro Pazopanib (GW786034B; GlaxoSmithKline) is a novel multi-targeted, orally available, small-molecule tyrosine kinase inhibitor of VEGF receptor 1, VEGF receptor 2, and VEGF receptor 3 with IC50 values of 10 nM, 30 nM, and 47 nM. Pazopanib (GW786034B; GlaxoSmithKline) also shows inhibition to platelet-derived growth factor receptor (including PDGFR-alpha and PDGFR-beta), and c-kit, FGF-R1, and c-fms with IC50 of 84, 74, 140, and 146 nM. Pazopanib can inhibit MM cell growth, survival, and migration. It can inhibit MM cell lines including dexamethasone-sensitive MM.1S, dexamethasone resistant MM.1R, doxorubicin (Dox)-sensitive RPMI, Dox-resistant RPMI (Dox40), IL-6-dependent INA-6, OPM2, and U266. Pazopanib suppresses VEGF-Induced Endothelial Cell Proliferation and Migration. category Inhibitors(c1514) cas_num 635702-64-6 Basic Info-
Product Name:
Pazopanib hydrochloride
Other Name:Benzenesulfonamide,5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-,hydrochloride (1:1);Benzenesulfonamide,5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-,monohydrochloride;Pazopanib hydrochloride;GW 786034B;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide hydrochloride
CAS No.:635702-64-6
Molecular Formula:C21H23N7O2S.ClH
InChIKeys:InChIKey=MQHIQUBXFFAOMK-UHFFFAOYSA-N
Molecular Weight:473.987
Exact Mass:473.140076
EC Number:1308068-626-2
Categories:
Characteristics-
PSA:
127
XLogP3:5.79510
Boiling Point:728.8ºC at 760 mmHg
Flash Point:394.6ºC
Water Solubility:In water, 3.3 mg/L at 25 deg C (est)
Storage Conditions:Store at room temperature between 20 deg C and 25 deg C (68 deg F to 77 deg F); excursions permitted to 15 deg C to 30 deg C (59 deg F to 86 deg F).
Vapor Pressure:3.21X10-14 mm Hg at 25 deg C (est)
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Russia
Pazopanib hydrochloride
100 KG Dec 10, 2024 
Pakistan
Pazopanib hydrochloride
1 KG May 23, 2025 Post an enquiry for this product