Isooctanol

130.22800

130.13600

248-133-5

IJF7D6C38T

0497

1993

DTXSID7029457|DTXSID2044634|DTXSID50872375

Clear, colorless liquid.

2905169000

20.23000

2.19510

Isooctyl alcohol appears as a clear colorless liquid with a faint pleasant odor. Flash point 180°F. Less dense than water and insoluble in water. Vapors are heavier than air. Used as a solvent, in the making of cutting and lubricating oils, in hydraulic fluids, and in the production of other chemicals.

0.832 g/cm³ @ Temp: 20 °C

<100 °C

186 °C @ Press: 800 Torr

71.1ºC

Index of refraction = 1.4251 at 25 °C/D

Insoluble

0.4 mmHg

Relative vapour density (air = 1): 4.5

Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

Explosive limits , vol% in air: 0.9-5.7 (estimated)

Mild

Henry's Law constant = 9.2X10-5 atm-cu m/mol at 25 °C (est)

1.95 mm Hg at 50 °C (extrapolated)|Hydroxyl radical reaction rate constant = 1.25X10-11 cu cm/molec-sec at 25 °C (est)

Insoluble in water.

Alcohols and Polyols

ISOOCTYL ALCOHOL attacks plastics. REF [Handling Chemicals Safely, 1980. p. 236]. Acetyl bromide reacts violently with alcohols or water, [Merck 11th ed., 1989]. Mixtures of alcohols with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions. Example: An explosion will occur if dimethylbenzylcarbinol is added to 90% hydrogen peroxide then acidified with concentrated sulfuric acid. Mixtures of ethyl alcohol with concentrated hydrogen peroxide form powerful explosives. Mixtures of hydrogen peroxide and 1-phenyl-2-methyl propyl alcohol tend to explode if acidified with 70% sulfuric acid, [Chem. Eng. News 45(43):73(1967); J, Org. Chem. 28:1893(1963)]. Alkyl hypochlorites are violently explosive. They are readily obtained by reacting hypochlorous acid and alcohols either in aqueous solution or mixed aqueous-carbon tetrachloride solutions. Chlorine plus alcohols would similarly yield alkyl hypochlorites. They decompose in the cold and explode on exposure to sunlight or heat. Tertiary hypochlorites are less unstable than secondary or primary hypochlorites, [NFPA 491 M, 1991]. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

530 °F (USCG, 1999)|530 °F (277 °C) (est)|277 °C (estimated)

Liquid: 1262.0 Kcal/g

Lower flammable limit: 0.9% by volume|0.9% (Calc), 5.7% (est)|Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

140 Btu/lb= 77 cal/g= 3.2X10+5 J/kg (est)

III

UN 3082

NS7700000

Separated from strong oxidants.

P210, P260, P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P309+P311, P312, P314, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, P501

H227

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Reacts with strong oxidants.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. Substance may be transported hot. For hybrid vehicles, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. If molten aluminum is involved, refer to ERG Guide 169. (ERG, 2016)|Combustible. Above 82 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

|Danger|H302 (80.47%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P337+P313, P362, and P501|Aggregated GHS information provided by 553 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H227 (50%): Combustible liquid [Warning Flammable liquids]|P210, P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P309+P311, P312, P314, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. The worker should wash daily at the end of each work shift. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. (NIOSH, 2016)|Air-supplied mask in confined areas; plastic gloves; goggles; eye bath and safety shower.|Wear rubber gloves, a face shield, coveralls and a multipurpose gas mask.|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.|(See protection codes)

Explosive limits , vol% in air: 0.9-5.7 (estimated)

Extinguish with water, foam, dry chemical, or carbon dioxide, cool exposed containers with water.

Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|The worker should immediately wash the skin when it becomes contaminated.|The worker should wash daily at the end of each work shift, and prior to eating, drinking, smoking, etc..|Work clothing that becomes wet or significantly contaminated should be removed and replaced.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Potential symptoms of overexposure are irritation of eyes, skin, nose, throat; eye and skin burns.|Liquid contact with eyes causes severe irritation and possible eye damage.

Vacated 1989 OSHA PEL TWA 50 ppm (270 mg/cu m), skin designation, is still enforced in some states.

Recommended Exposure Limit: 10 Hr Time-Weighted avg: 50 ppm (270 mg/cu m), skin.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Separated from strong oxidants.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.

The substance defats the skin, which may cause dryness or cracking.

NO open flames. Above 82 °C use a closed system and ventilation.

Use ventilation.

Protective gloves.

Wear safety goggles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Isooctyl alcohol is produced, as an intermediate or final product, by process units covered under this subpart.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Isooctyl alcohol was qualitatively detected in sediments from Lake Tobin of the Saskatchewan River, Canada(1).

LD50 Rat oral 1.5 g/kg|LD50 Rat oral 3.2 g/kg|LD50 Mouse single oral 6.4 g/kg|LD50 Guinea pig /dermal/ > 10 ml/kg|LD50 Rabbit dermal >2.6 g/kg

Isooctyl alcohol's production and use as an ingredient of plasticizers, intermediate for nonionic detergents and surfactants, synthetic drying oils, cutting and lubricating oils, hydraulic fluids; resin solvents; emulsifiers; antifoaming agent; and an intermediate for introducing the isooctyl group into other compounds(1) may result in its release to the environment through various waste streams.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 125(SRC), determined from a water solubility of 640 mg/L(2) and a regression-derived equation(3), indicates that isooctyl alcohol is expected to have high mobility in soil(SRC). Volatilization of isooctyl alcohol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.2X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 0.344 mm Hg(4), and water solubility(2). Isooctyl alcohol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Based on analogy to n-octanol isomers, isooctyl alcohol may biodegrade rapidly in acclimated terrestrial environments(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 125(SRC), determined from a water solubility of 640 mg/L(2) and a regression-derived equation(3), indicates that isooctyl alcohol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 9.2X10-5 atm-cu m/mole(SRC), derived from its extrapolated vapor pressure, 0.344 mm Hg(4), and water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 14 hours and 7.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 16(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Based on analogy to n-octanol isomers, isooctyl alcohol may biodegrade rapidly in acclimated aquatic systems(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isooctyl alcohol, which has an extrapolated vapor pressure of 0.344 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isooctyl alcohol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.3 days(SRC), calculated from its rate constant of 1.2X10-11 cu cm/molecule-sec at 25 °C(3).

The rate constant for the vapor-phase reaction of isooctyl alcohol with photochemically-produced hydroxyl radicals has been estimated as 1.2X10-11 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 1.3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(SRC). Alcohols are resistant to hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Isooctyl alcohols absorb UV light at wavelengths <185 nm(3) and therefore are not expected to be susceptible to direct photolysis by sunlight.

An estimated BCF of 16 was calculated for isooctyl alcohol(SRC), using a water solubility of 640 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of isooctyl alcohol is estimated as 125(SRC), using a water solubility of 640 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that isooctyl alcohol is expected to have high mobility in soil.

The Henry's Law constant for isooctyl alcohol is estimated as 9.2X10-5 atm-cu m/mole(SRC) derived from its extrapolated vapor pressure, 0.344 mm Hg(1), and water solubility, 640 mg/L(2). This Henry's Law constant indicates that isooctyl alcohol is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 14 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 7.8 days(SRC). Isooctyl alcohol's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Isooctyl alcohol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 12,363 workers (3,300 of these are female) are potentially exposed to isooctyl alcohol in the US(1). Occupational exposure to isooctyl alcohol may occur through dermal contact with this compound at workplaces where isooctyl alcohol is produced or used(SRC). The general population may be exposed to isooctyl alcohol via dermal contact with this compound and other products containing isooctyl alcohol(SRC).

The air expired from humans contained isooctyl alcohol(1) in 15.8% of the 387 samples collected from 54 subjects(2). The average isooctyl alcohol concn of 1.3 ng/L was expressed as the geometric mean with upper and lower limits of 0.33 and 5.1 respectively(2).

Inhalation hazard slight. Skin contact results in moderate irritation. Liquid contact with eyes causes severe irritation and possible eye damage. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Artificial respiration may be needed.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic Treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Higher alcohols (>3 carbons) and related compounds/|Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques, with a bag-valve-mask device, may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose strip or glucometer readings below 50 mg) and administer 50% dextrose if necessary ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Higher alcohols (>3 carbons) and related compounds/

/SIGNS AND SYMPTOMS/ Symptomatology: Central nervous system: headache, muscle weakness, giddiness, ataxia, confusion, delirium, coma. Gastrointestinal: nausea, vomiting, diarrhea (odor of the alcohol in excreta). Irritation of skin, eyes, throat from vapor or liquid. Cough and dyspnea. Death from respiratory failure. Disturbances of cardiac rhythm. Occasional complications: a. Gastrointestinal hemorrhage b. Renal damage with glycosuria c. Liver damage d. Cardiac failure e. Pulmonary edema. /Alcohols, higher/

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, skin, nose, throat; eye, skin burns

Cough. Dizziness. Lethargy. Headache. Nausea. Sore throat.

Dry skin. Redness.

Redness. Pain.

Eyes, skin, respiratory system

Isooctyl alcohols or isooctanols are mixtures of isomeric C8 alcohols ... The commercial product typically consists of methyl-1-heptanols and/or dimethyl-1-hexanols; the composition and CAS registry number depend on the olefin feedstock.

All other basic organic chemical manufacturing|Isooctanol: ACTIVE|Alcohols, C7-9-iso-, C8-rich: ACTIVE|Alcohols, C7-9-branched: INACTIVE|Usually refers to a mixture of isomers made by the Oxo process.|A mixture of closely related isomeric branched-chain primary alcohols: RCH2OH where R represents a branched heptyl radical. The branching consists mostly of methyl groups located in the 3-, 4-, or 5-positions.|Commercial products from the family of 6 to 11 carbon alcohols that make up the plasticizer range are available both as ... pure single carbon chain materials and as complex isomeric mixtures. Commercial descriptions of plasticizer range alcohols are ... in general a ... pure material is called "-anol" /eg, 1-octanol/, and the mixtures are called "-yl alcohol /eg, octyl alcohol/ or "iso...yl alcohol" /eg, isooctyl alcohol/.

Method: OSHA PV2033; Procedure: gas chromatography with flame ionization detector; Analyte: isooctyl alcohol; Matrix: air; Detection Limit: 41.5 ug.

Fire Hazards -> Flammable - 2nd degree