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1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)

1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1) structure

CAS No:
138786-67-1
Formula:
C16H15F2N3O4S.Na
Chemical Name:
1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
Synonyms:
1H-Benzimidazole,6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-,sodium salt (1:1);1H-Benzimidazole,5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-,sodium salt;Pantoprazole sodium;Protonix;Controloc;Pantoloc;Pantoprazole sodium salt;Zurcal;5-Difluoromethoxy-2-[[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole sodium salt;Pantecta;Nolpaza;Somac;142678-34-0;226904-33-2
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

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Description

Pantoprazole sodium salt(SKF96022; Protonix) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.IC50 value:Target: proton pump inhibitor

1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1) Basic Attributes

Molecular Weight：

405.35

Exact Mass：

405.05700

EC Number：

1312995-182-4

HScode：

2933990090

Characteristics

PSA：

90.8

XLogP3：

3.53580

Appearance：

white to off-white solid

Melting Point：

>130 °C (decomp)

Boiling Point：

586.9°C at 760 mmHg

Flash Point：

308.7ºC

Storage Conditions：

-20°C Freezer

Safety Information

hazard class code：

20/21/22-37/38-41-48

safety instructions：

22-26-36/37/39-45

Marks：

1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1) Use and Manufacturing

Gastrointestinal

Drug Function and Efficacy

This product acts specifically on the gastric mucosal parietal cells, reducing the activity of H/KATPase in the parietal cells, thereby inhibiting the secretion of gastric acid. Compared with omeprazole and lansoprazole, this product has a weaker inhibitory effect on cytochrome P450-dependent enzymes. No adverse effects were found in either short-term or long-term administration of pantoprazole. This drug is non-carcinogenic, does not impair fertility, and does not induce teratogenesis. After 2.5 years of continuous medication, there were no changes in various experimental parameters of liver enzymology and cholesterol metabolism.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pantoprazole Sodium for Injection
Ingredients	Pantoprazole sodium.
Indication	1. In vivo, higher doses of pantoprazole do not change the elimination rate of diazepam, and its serum concentration is not affected by diazepam, indicating that diazepam does not affect the metabolism of pantoprazole. 2. Pantoprazole has no interaction with aminophylline, warfarin, contraceptives, phenytoin sodium, nifedipine, aminopyrine, digoxin, diclofenac, metoprolol and antacids.
Specifications	40mg
Manufacturer	Hainan Weikang Pharmaceutical(Qianshan) Co., Ltd.

Pantoprazole Sodium for Injection
Ingredients	Pantoprazole sodium.
Indication	1. In vivo, higher doses of pantoprazole do not change the elimination rate of diazepam, and its serum concentration is not affected by diazepam, indicating that diazepam does not affect the metabolism of pantoprazole. 2. Pantoprazole has no interaction with aminophylline, warfarin, contraceptives, phenytoin sodium, nifedipine, aminopyrine, digoxin, diclofenac, metoprolol and antacids.
Specifications	80mg
Manufacturer	Hebei Aier Haitai Pharmaceutical Co., Ltd.

Pantoprazole sodium
Manufacturer	Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

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Registered Holders

AZICO BIOPHORE INDIA PRIVATE LTD

United States
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MANKIND PHARMA LTD

United States
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METROCHEM API PRIVATE LTD

United States
Active

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Guide of 1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)

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