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Diclofenac diethylamine

Diclofenac diethylamine structure

CAS No:
78213-16-8
Formula:
C14H11Cl2NO2.C4H11N
Chemical Name:
Diclofenac diethylamine
Synonyms:
Benzeneacetic acid,2-[(2,6-dichlorophenyl)amino]-,compd. with N-ethylethanamine (1:1);Ethanamine,N-ethyl-,2-[(2,6-dichlorophenyl)amino]benzeneacetate;Diclofenac diethylammonium salt;Voltaren Emulgel;Diclofenac diethylamine salt;Diclofenac diethylamine;Atomo Desinflamante;Voltaren Schmerzgel;Dynapar QPS
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.

Diclofenac diethylamine Basic Attributes

Molecular Weight：

369.29

Exact Mass：

368.105835

EC Number：

1806241-263-5

UNII：

6TGQ35Z71K

HScode：

2942000000

Characteristics

PSA：

61.4

XLogP3：

5.44380

Melting Point：

145-148 °C @ Solvent: Diethyl ether, Ligroine

Boiling Point：

412ºC at 760 mmHg

Flash Point：

203ºC

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 61 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

diclofenac diethylamine

Diclofenac diethylamine Use and Manufacturing

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Computed Properties

Molecular Weight:369.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:368.1058333
Monoisotopic Mass:368.1058333
Topological Polar Surface Area:61.4
Heavy Atom Count:24
Complexity:315
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Prostaglandin synthesis inhibitor, with anti-inflammatory and analgesic effects. Topical application of its active ingredients can penetrate the skin to reach the inflamed area, relieve acute and chronic inflammatory reactions, reduce inflammatory swelling, and relieve pain.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Diclofenac diethylamine emulsion
Ingredients	Each vial of this product contains 0.5 grams of diclofenac diethylamine (calculated as diclofenac sodium) and excipients such as isopropyl alcohol and propylene glycol.
Indication	1. There is no report of interaction with other drugs. 2. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	50g/piece

Diclofenac diethylamine emulsion
Specifications	1% (20g: 0.2g; 50g: 0.5g; 75g: 0.75g, calculated as C14H10Cl2NNaO2)

Diclofenac diethylamide

See More Related Drugs

Registered Holders

AMOLI ORGANICS (A DIVISION OF UMEDICA LABORATORIES PVT LTD)

United States
Active
Shandong Guomao Enterprise Management Co., Ltd.

China
Active
Hunan OUYA Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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