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Venlafaxine hydrochloride

Venlafaxine hydrochloride structure

CAS No:
99300-78-4
Formula:
C17H27NO2.ClH
Chemical Name:
Venlafaxine hydrochloride
Synonyms:
Cyclohexanol,1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-,hydrochloride (1:1);Cyclohexanol,1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-,hydrochloride;Wy 45030;Venlafaxine hydrochloride;Effexor;Efexor;Wy 4530;Venlafaxin hydrochloride;Ventab XL;Vexor;Venlift;VENIZ-XR;VENTAB;1-(2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride;93413-78-6
Categories:
Biochemical Engineering > Inhibitors

Description

Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.Target: SNRIVenlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. First introduced by Wyeth in 1993, now marketed by Pfizer, it is licensed for the treatment of major depressive disorder (MDD), as a treatment for generalized anxiety disorder, and comorbid indications in certain anxiety disorders with depression. In 2007, venlafaxine wa

A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.

Venlafaxine hydrochloride Basic Attributes

Molecular Weight：

313.86

Exact Mass：

313.180847

EC Number：

200-659-6

NSC Number：

745751

DSSTox ID：

DTXSID8047397

HScode：

2922509090

Characteristics

PSA：

32.7

XLogP3：

0.43 (LogP)

Appearance：

white

Density：

1.394 g/cm3

Melting Point：

215-217 °C

Flash Point：

9℃

Water Solubility：

H2O: >10mg/mL

Storage Conditions：

Store at RT

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

36/37/38-36-39/23/24/25-23/24/25-11

safety instructions：

26-37/39-45-36/37-16-7

RTECS Number：

GV8872760

Marks：

Xi,T,F

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

GHS Classification：

|Warning|H302 (30.51%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P260, P263, P264, P270, P280, P301+P312, P305+P351+P338, P308+P313, P330, P337+P313, and P501|Aggregated GHS information provided by 60 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)|Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)

MeSH Entry Terms：

1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol HCl

Venlafaxine hydrochloride Use and Manufacturing

Uses

Venlaxafine is an inhibitor of reuptake of both serotonin (IC50 = 0.21 μM) and norepinephrine (IC50 = 0.64 μM). It is effective in vitro and in vivo and against human as well as rat receptors. As an antidepressant, it is properly placed in the serotonin-norepinephrine reuptake inhibitor class.[Cayman Chemical]

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:313.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:313.1808568
Monoisotopic Mass:313.1808568
Topological Polar Surface Area:32.7
Heavy Atom Count:21
Complexity:279
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Cyclohexanone

Hexane

Sodium hydroxide

Formaldehyde

Formic acid

Isopropanol

Hydrochloric acid

Ammonia

Drug Function and Efficacy

Venlafaxine and its active metabolite O-desmethylvenlafaxine are strong inhibitors of 5-HT and NE reuptake and weak inhibitors of dopamine. In vitro tests have not found that venlafaxine and O-desmethylvenlafaxine have significant affinity for M cholinergic receptors, H1 histamine receptors, and α1-adrenergic receptors. Venlafaxine and O-desmethylvenlafaxine have no MAO inhibitory activity. Animal experiments have shown that venlafaxine has analgesic effects on pain models of mice or rats caused by acetic acid, brewer's yeast, and photothermal stimulation.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Venlafaxine Hydrochloride Capsules
Ingredients	The main component is venlafaxine hydrochloride. Chemical name: (±)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol hydrochloride.
Indication	Alcohol Patients should be advised to avoid drinking alcohol while taking venlafaxine. Cimetidine The combined use of venlafaxine and cimetidine will inhibit the first-pass metabolism of venlafaxine. The clearance of oral venlafaxine is reduced by approximately 43%, and the AUC and Cmax of the drug are increased by approximately 60%, but the combined use of cimetidine has no effect on the metabolism of ODV. Because the amount of ODV in the blood circulation is much greater than venlafaxine, the additive pharmacological effect of venlafaxine and ODV is only slightly enhanced, and the dosage of the drug does not need to be adjusted for most adults. However, for patients with pre-existing hypertension, the elderly, and patients with impaired liver function, the interaction between venlafaxine and cimetidine may be more significant and should be used with caution. Diazepam Diazepam has an effect on the metabolism of venlafaxine and
Specifications	25mg
Manufacturer	Chengdu Brilliant Pharmaceutical Co., Ltd.

Venlafaxine Hydrochloride Capsules
Ingredients	Venlafaxine hydrochloride. Molecular formula: C17H27NO2HCl Molecular weight: 313.87
Indication	1. When used in combination with selective serotonin reuptake inhibitors or monoamine oxidase inhibitors, it can cause hypertension, rigidity, myoclonus, involuntary movement, anxiety, impaired consciousness, and even coma and death. Therefore, when switching from one drug to another, a wash-out period of 7 to 14 days is required. 2. When used in combination with quinidine, the blood concentration of this product can be increased. 3. When used in combination with ?-receptor blockers propranolol, metoprolol, timolol or with tricyclic antidepressants amitriptyline, clomipramine, imipramine or with antiarrhythmic drugs propranolone, codeine and dextromethorphan, it can competitively inhibit the metabolism of this product. 4. When used in combination with cimetidine, the clearance rate of this product can be reduced.
Specifications	25mg
Manufacturer	Shanghai New Asiatic Medicine Industry Minhang Co., Ltd.

Venlafaxine Hydrochloride

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Registered Holders

MSN LIFE SCIENCES PRIVATE LTD

United States
Active
AMOLI ORGANICS (A DIVISION OF UMEDICA LABORATORIES PVT LTD)

United States
Active
MEGAFINE PHARMA P LTD

United States
Active

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Guide of Venlafaxine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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