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Doramectin

Doramectin structure

CAS No:
117704-25-3
Formula:
C50H74O14
Chemical Name:
Doramectin
Synonyms:
Avermectin A1a,25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)-;Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran],avermectin A1a deriv.;25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a;Doramectin;UK 67994;25-Cyclohexylavermectin B1;Dectomax;L 701023;Doramectin A1a;Treo ACE;Treo Ace Injetavel;157544-18-8
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

So the effect of doramectin to drive and to kill the parasites is stronger than ivermectin, and it can be effective to prevent the parasite reinfection.

Doramectin Basic Attributes

Molecular Weight：

899.11

Exact Mass：

899.11

EC Number：

1308068-626-2

HScode：

29419090

Characteristics

PSA：

170

XLogP3：

5.91160

Appearance：

white

Density：

1.25±0.1 g/cm3(Predicted)

Melting Point：

116-119 °C

Boiling Point：

967.4±65.0 °C(Predicted)

Flash Point：

274.4±27.8 °C

Refractive Index：

1.580

Water Solubility：

methanol: soluble

Storage Conditions：

0-6°C

Vapor Pressure：

0mmHg at 25°C

Safety Information

Packing level：

Ⅲ

Transport codes：

UN28116.1/PG3

wgk germany：

hazard class code：

25-50/53-36/37/38

safety instructions：

33-45-60-61-36/37-26

Marks：

T,N,Xi

Precautionary statement(s)：

P273-P301 + P310-P501

Hazard Statements：

H301-H410

Doramectin Use and Manufacturing

Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins Doramectin is used for the treatment of ectoparasitic diseases such as nematode diseases and mites of domestic animals. It is obtained by fermentation of a new strain of Streptomyces avermitilis with genetic recombination. The main difference from ivermectin is that the C25 position is substituted by cyclohexyl. It is a new and broad-spectrum antiparasitic drug, which is highly effective against gastrointestinal nematodes, lung nematodes, euglena, lice, ticks, mites and wound maggots, and against internal and external parasites, especially certain nematodes (roundworms) and Arthropods also have a good repellent effect, but they are not effective against tapeworms, flukes and protozoa. Its mechanism of action is mainly to increase the release of the inhibitory transmitter γ-aminobutyric acid (GABA) of the worm, thereby blocking the transmission of nerve signals, making muscle cells lose the ability to contract, and causing the death of the worm.

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