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Cefoxitin sodium

Cefoxitin sodium structure

CAS No:
33564-30-6
Formula:
C16H17N3O7S2.Na
Chemical Name:
Cefoxitin sodium
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,sodium salt (1:1),(6R,7S)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt,(6R-cis)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt,(6R,7S)-;Cefoxitin sodium salt;Cefoxitin sodium;Cenomycin;Monosodium cefoxitin;Mefoxin;Merxin;Mefoxithin;Mefoxitin;MK 306;Farmoxin;Betacef;Cefaxilin sodium;Sodium cefoxitin;41224-60-6;51829-86-8
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefoxitin sodium (MK-306) is a cephamycin antibiotic, often grouped with the second generation cephalosporins, acts by interfering with cell wall synthesis, its activity spectrum includes a broad range of gram-negative and gram-positive bacteria.

Cefoxitin sodium Basic Attributes

Molecular Weight：

449.43

Exact Mass：

449.032745

EC Number：

252-641-2

HScode：

29419000

Characteristics

PSA：

205

XLogP3：

-0.20700

Appearance：

White to almost white powder

Melting Point：

>160°C

Boiling Point：

843℃

Flash Point：

>110°(230°F)

Water Solubility：

soluble in water or methanol

Storage Conditions：

2-8°C

Toxicity：

Intravenous-rat LD50: 8580 mg/kg; Intravenous-mouse LD50: 4970 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides, sulfur oxides, sodium oxide fumes

Specific rotation：

25589nm +210° (c = 1 in methanol)

Safety Information

Packing level：

III

Hazard category：

Transport codes：

3077

wgk germany：

hazard class code：

36/37/38-42/43

safety instructions：

22-26-36/37-36/37/39

RTECS Number：

XI0330500

Marks：

Xn,Xi

Storage features：

The warehouse is low-temperature, ventilated and dry

Precautionary statement(s)：

P280

Hazard Statements：

H317

Toxicity

Toxicity class：

practically nontoxic

Cefoxitin sodium Use and Manufacturing

Methods of Manufacturing

Compound IV287.1 lg, THF was added to a three-necked reaction flask, cooled, Add 158.97 g of pre-cooled chlorosulfonyl isocyanate in portions and stir until fully reacted. The reaction solution was poured into precooled distilled water, stirred for 2 h, ethyl acetate was added, the insoluble material was filtered and a 10percent sodium chloride solution was added to the filtrate. Stir for 1 Omin. The organic layer was washed with 10percent sodium chloride solution and adjusted to pH 2.0 with 2 mol / L hydrochloric acid. The white crystals were allowed to stand overnight and filtered. The filter cake was washed with ethyl acetate and dried in vacuo. Obatined Cefoxitin acid. Add acetone solution at 30 ° C, add sodium lactate 2.0g, stirring lOmin, then add acetone, the resulting solid filtration drying in vacuum to give cefoxitin sodium 319.59g (yield 95percent, purity 99.5percent).

Uses

An antibiotic derived from Cephamycin C.

Price Analysis

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Drug Function and Efficacy

It kills bacteria by inhibiting bacterial cell wall synthesis and has high resistance to β-lactamase produced by bacteria. Some common Gram-positive, Gram-negative aerobic and anaerobic pathogens are highly sensitive to this product. It is resistant to Pseudomonas aeruginosa, most strains of enterococci, and Escherichia coli.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefoxitin Sodium for Injection
Ingredients	The main ingredient of this product is cefoxitin sodium, and its other scientific name is: (6R,7S)-3-carbamoyloxymethyl-7-methoxy-8-oxo-7-[2(2-thienyl)acetylamino]-5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid sodium salt.
Indication	Not yet clear.
Specifications	1.0g (calculated as C16H17N3O7S2)

Cefoxitin Sodium for Injection
Ingredients	The main ingredient of this product is cefoxitin sodium, and its chemical name is 3-hydroxymethyl-7-a-methoxy-8-keto-7[2(2-thiophene)ethylphenolamino]-5-thio-1-azabicyclo-4,2,0-oct-2-ene-acetic anhydride acyl (sodium salt).
Indication	The simultaneous use of cephalosporins and aminoglycosides can increase renal toxicity. At high concentrations, this product can cause a false slight increase in plasma and urine creatinine levels and urine 7-hydroxycortisol levels, which may cause a false positive reaction to urine sugar.
Specifications	1.0g (calculated as C16H17N3O7S2)
Manufacturer	CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

Cefoxitin Sodium for Injection
Specifications	0.5g (calculated as C16H17N3O7S2)
Manufacturer	Liaoning Tianlong Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Guangzhou HC Pharmaceutical Co., Ltd.

China
Active
China UNION Chempharma (SUZHOU) Co., Ltd.

China
Active
Suzhou Wanqing Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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