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Imidocarb

Imidocarb structure

CAS No:
27885-92-3
Formula:
C19H20N6O
Chemical Name:
Imidocarb
Synonyms:
Urea,N,N′-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-;Carbanilide,3,3′-di-2-imidazolin-2-yl-;N,N′-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea;3,3′-Bis-(2-imidazolin-2-yl)carbanilide;Imidocarb;Piro-Stop;1,3-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Imidocarb is a member of ureas. It has a role as an antiprotozoal drug.|Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites.|One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock. Toxicity has been reported.

Imidocarb Basic Attributes

Molecular Weight：

348.4

Exact Mass：

348.40

EC Number：

248-711-7

UNII：

8USS3K0VDH

DSSTox ID：

DTXSID0048345

Characteristics

PSA：

89.9

XLogP3：

-0.45

Appearance：

white powder

Density：

1.4±0.1 g/cm3

Boiling Point：

677.1ºC at 760 mmHg

Flash Point：

363.3ºC

Refractive Index：

1.724

Vapor Pressure：

2.94E-19mmHg at 25°C

Safety Information

Precautionary statement(s)：

P201, P202, P260, P264, P270, P281, P301+P312, P307+P311, P308+P313, P314, P321, P330, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P281, P301+P312, P307+P311, P308+P313, P314, P321, P330, P405, and P501|Aggregated GHS information provided by 36 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)

MeSH Entry Terms：

Dihydrochloride, Imidocarb

Imidocarb Use and Manufacturing

Methods of Manufacturing

The ethyl m-nitrobenzoate was reacted with ethylenediamine in the presence of trimethylaluminum to prepare 2-(3-nitrobenzene)imidazoline with a yield of 90%. It is then reduced to 2-(3-aminobenzene) imidazoline, and finally phosgenated to obtain imidazole urea through condensation.

Uses

Imidocarb is a urea derived antiprotozoal agent used in veterinary medicine for the treatment of infection with babesia and other parasites. This product is an anti-pyroworm disease drug with the characteristics of high curative effect, low toxicity and small dosage. Severely infected cattle, sheep, and babesiella disease can be quickly controlled by treatment with imidazolium, and no recurrence has been seen after three months of treatment. This product also has a preventive effect on pyometriosis.

Computed Properties

Molecular Weight:348.4
XLogP3:0.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:348.16985928
Monoisotopic Mass:348.16985928
Topological Polar Surface Area:89.9
Heavy Atom Count:26
Complexity:526
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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