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Pullulan

pharmaceutical raw materials
Pullulan structure

Pullulan 

structure
  • CAS No:

    9057-02-7

  • Formula:

    C20H36O16

  • Chemical Name:

    Pullulan

  • Synonyms:

    Pullulan Standard 200μ000;Pullulan Standard 6μ000;Pullulan Standard 400μ000;Pullulan Standard 110μ000;Pullulan Standard 320;Pullulan Standard Set;Pululan;PULLULAN STANDARD 340

  • Categories:

    Biochemical Engineering  >  Saccharides

Description

water soluble


Pullulan is a water-soluble, linear homopolysaccharide of glucose that is produced extracellularly by certain strains of the Aureobasidium pullulans fungus. This polysaccharide possesses adhesive properties and can be utilized to create strong, compression moldings, fibers, and oxygen-impermeable films. In the food industry, pullulan films are frequently used as coating or packaging material for dried foods, as a binder for tobacco, plant fertilizers, and seed coatings, as a low-viscosity filler in sauces and beverages, as well as a stabilizer and binder in food pastes. Additionally, this polysaccharide is often used to halt fungal growth in food. As for pharmaceutical applications, pullulan is used as a denture adhesive and an ingredient in sugar-coated pharmaceutical compositions to prevent the development of brownish coloring. Finally, pullulan finds application in lotions, shampoos, and cosmetics.


It is a white, tasteless, and odorless non-crystalline powder that dissolves easily in water and dimethylformamide, but not in alcohol, ether, or oil. Its solution is viscous, stable, and neutral, with no gelling effect. The viscosity of the solution is the same as that of gum arabic, and it has a very good thickening effect of salt resistance, enzyme resistance, heat resistance, and pH value change resistance. It has strong film-forming properties, and the film formed after its aqueous solution is dried on a metal plate has strong gas barrier properties to oxygen and nitrogen. Moreover, it is suitable for making water-soluble edible films and is compatible with other water-soluble polymers.


pullulan: A water-soluble polysaccharidecomposed of glucose unitsthat are polymerized in such a wayas to make it viscous and impermeableto oxygen. Pullulan is used in adhesives, food packaging, andmoulded articles. It is derived fromthe fungus Aureobasidium pullulans.


Pullulan Standards are mostly used to obtain molecular mass distribution of cellulosic samples. It mainly consists of polymaltotriose units linked together by α-(1→6) linkages. Pullulan is a biodegradable polysaccharide made by yeast fermentation, originally developed in Japan. Its adhesive and oxygen impermeable properties enable it to be used to coat pharmaceutical products. It is water soluble, odorless, and edible.

Pullulan Basic Attributes

532.49024

574.247314

232-945-1

TSCA listed

White to Off-white

29400090

Characteristics

257.68000

-5.21

White to Off-white Powder

1.5±0.1 g/cm3

>248°C (dec.)

854.6±65.0 °C at 760 mmHg

470.6±34.3 °C

1.574

water: 50mg/mL, colorless to very faintly yellow

2-8°C

at 100.00%. odorless

2-8°C

Safety Information

NONH for all modes of transport

3

24/25

UO5470000

Pullulan Use and Manufacturing

Methods of Manufacturing

Black yeast (Pullular such as pullulans, also known as AureobasidIum pullulans) is cultured in aeration medium (27-30℃, 4-7 days) containing starch hydrolysate (usually caramel) and inorganic salts, and then heated, The cells are removed by centrifugation, the filtrate is precipitated with an equal amount of ethanol, and then purified by dissolving and refining with water.

Uses

serum amylase substrate


Pullulan has been used in a study to assess bone tissue engineering. It has also been used in a study that investigated anti-fog applications.

Production

Pullulan is produced by fermentation from a food-grade hydrolyzed search with a non-toxin-producing strain of Aureobasidium pullulans. After fermentation, the fungal biomass is removed by microfiltration, the filtrate is heat-sterilized, and pigments and other impurities are removed by adsorption and ion exchange chromatography. The product contains not less than 90% glucan on a dried basis. The main impurities from the starting material are mono-, di-, and oligosaccharides. The average relative molecular mass of pullulan varies considerably depending on the conditions of the culture. A commercially available product has an average relative molecular mass of 200 000 Da.

Drug Function and Efficacy

Film-forming agent, provides a smooth texture

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • Lin Yuan International Limited Shanghai Representative Office

    China China
    Active
  • Shandong Kang Naxin Biotechnology Co., Ltd.

    China China
    Active
  • HAYASHIBARA CO LTD

    United States United States
    Active

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