2-Ethylhexanal Safety Data Sheets

Flammable liquids, Category 3

Skin sensitization, Sub-category 1B

Reproductive toxicity, Category 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

Inhalation may be irritating to mucous membrane; overexposure may cause dizziness and collapse. Ingestion causes irritation of mouth and stomach. Contact with eyes or skin causes irritation. (USCG, 1999)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

Use powder, AFFF, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance.

Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep ethyl hexaldehyde out of a confined space, such as a sewer, because of the possibility of an explosion ...

NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Above 46°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from acids, bases and oxidants. Cool. Well closed.Store in tightly closed containers in a cool, well ventilated area away from oxidizers, strong bases and combustible materials.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

The substance can form explosive peroxides on prolonged contact with oxygen or air. The substance polymerizes on contact with sodium hydroxide, ammonia, butyl- and dibutylamine and inorganic acids. Reacts with oxidants.

no data available

Dangerous fire hazard; spontaneously flammable in air.The vapour is heavier than air.2-ETHYLHEXALDEHYDE is an aldehyde. Aldehydes are frequently involved in self-condensation or polymerization reactions. These reactions are exothermic; they are often catalyzed by acid. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation.

no data available

Forms explosive mixture with air. Violent reaction with oxidizers. Incompatible with strong acids, caustics, ammonia, amines.

When heated to decomposition it emits acrid and irritating fumes.

Acute toxicity

• Oral: LD50 - rat (male/female) - ca. 3.2 mL/kg bw.
• Inhalation: LC50 - rat (male/female) - > 6.83 mg/L air.
• Dermal: LD50 - rat (male/female) - > 16 440 mg/kg bw.

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 5.5 mg/L - 96 h.
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 4.7 mg/L - 48 h.
• Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 6.9 mg/L - 72 h.
• Toxicity to microorganisms: EC0 - activated sludge, domestic - 48.8 mg/L - 30 min. Remarks:Respiration rate.

AEROBIC: Using OECD Method 301F (Ready Biodegradability, Manometric Respirometry Test) with a domestic activated sludge inoculum and a 28-day incubation period, 2-ethylhexaldehyde had a theoretical BODT of 71.8%(1) which classifies it as readily biodegradable(SRC). By analogy, isobutyraldehyde (a structurally similar branched saturated aldehyde to 2-ethylhexaldhyde), present at 30 mg/L, reached 81% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 100 mg/L in the Japanese MITI test(2).

An estimated BCF of 49 was calculated in fish for 2-ethylhexaldehyde(SRC), using a log Kow of 3.07(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2-ethylhexaldehyde can be estimated to be 18(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-ethylhexaldehyde is expected to have very high mobility in soil(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Check for peroxides prior to distillation; eliminate if found.