2-Naphthylamine Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 2-naphthylamine |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 2-Naftylamine; naphthalen-2-ylamine; naphthalene-2-amine |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research uses. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Carcinogenicity, Category 1A
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H302 Harmful if swallowed H350 May cause cancer H411 Toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment. |
| Response | P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P391 Collect spillage. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-naphthylamine | 2-naphthylamine | 91-59-8 | 202-080-4 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention .
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Cover skin bums with dry sterile dressings after decontamination . /Organic bases/Amines and related compounds/
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources.
5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)
5.3 Special protective actions for fire-fighters
Use water spray, dry powder, foam.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Sweep spilled substance into covered containers. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. PREVENT DISPERSION OF DUST. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Well closed. Store in an area without drain or sewer access.Separated from food and feedstuffs. Well closed.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
TLV: A1 (confirmed human carcinogen).MAK: skin absorption (H); carcinogen category: 1; germ cell mutagen group: 3A
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear face shield or eye protection in combination with breathing protection if powder.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use closed system or ventilation.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Beta-naphthylamine is a white to reddish colored solid in the form of flakes. Slightly soluble in hot water and denser than water. Toxic by ingestion, inhalation and skin absorption. Used to make dyes and agricultural chemicals. |
|---|---|
| Colour | COLORLESS CRYSTALS WHICH DARKEN IN AIR TO A REDDISH-PURPLE COLOR |
| Odour | Faint aromatic odor |
| Melting point/freezing point | 110.2 ~ 113 °C |
| Boiling point or initial boiling point and boiling range | 306 °C |
| Flammability | Combustible Solid |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 157 °C |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | WEAK BASE |
| Kinematic viscosity | no data available |
| Solubility | Partially miscible with water |
| Partition coefficient n-octanol/water | log Kow =2.28 |
| Vapour pressure | 1 mm Hg at 226.4° F ; 5 mm Hg at 286.9° F (NTP, 1992) |
| Density and/or relative density | 1.061 |
| Relative vapour density | 4.95 (NTP, 1992) (Relative to Air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
NIOSH considers beta-naphthylamine to be a potential occupational carcinogen.
Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides.
10.2 Chemical stability
Stable in cold in absence of air; oxidizes in presence of air; volatile in steam
10.3 Possibility of hazardous reactions
It is combustible and at elevated temperatures evolves a vapor which is flammable ... Fire hazard: moderate, when exposed to heat or flame.Dust explosion possible if in powder or granular form, mixed with air.BETA-NAPHTHYLAMINE is a weak base. It is incompatible with strong oxidizing agents and strong acids. It is also incompatible with nitrous acid. It reduces warm ammoniacal silver nitrate. (NTP, 1992)
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
STABILITY: This chemical darkens in air to a reddish-purple color (oxidizes).REACTIVITY: This chemical is a weak base. It is incompatible with strong oxidizing agents and strong acids. It is also incompatible with nitrous acid. It reduces warm ammoniacal silver nitrate. (NTP, 1992)
10.6 Hazardous decomposition products
When exposed to heat or flame, it emits toxic fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Sufficient evidence of carcinogenicity in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 1: The agent is a human carcinogen. From table
Reproductive toxicity
no data available
STOT-single exposure
The substance may be irritating to the respiratory tract and skin. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The substance may cause effects on the bladder. This may result in inflammation and blood in the urine. Medical observation is indicated. The effects may be delayed. See Notes.
STOT-repeated exposure
This substance is carcinogenic to humans. See Notes.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: In a test for primary biodegradation, 2-naphthylamine was not degraded in chernozem soil after 90 days at an initial concentration of 500 mg/kg(1). The maximum mineralization rate for 2-naphthylamine (conc. 50 ug/g) in a soil/water suspension over 220 days was 0.12 ug/g-day during a short initial phase and 0.027 ug/g-day during a longer second phase(2). Addition of fresh amounts of 2-naphthylamine (conc. 50 ug/g) at 220 days restored the mineralization to the initial phase rate value. The recalcitrance of aminonaphthalenes in soil has been attributed to their ability to form complexes with soil matter which, to a large extent, renders them biologically unavailable(3).
12.3 Bioaccumulative potential
An estimated BCF of 11 was calculated for 2-naphthylamine(SRC), using a log Kow of 2.28(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The measured Koc for 2-naphthylamine is 1,000(1). According to a classification scheme(2), this Koc value suggests that 2-naphthylamine is expected to have low mobility in soil. Results of a batch equilibrium study with various soils indicated that 1-naphthylamine, which is structurally analogous to 2-naphthylamine, binds to soil in two phases with an initial rapid and reversible equilibrium established between the amine and the inorganic and organic components of soil followed subsequently by a strong association with the humic fraction of soil via covalent binding(3,4). Aminonaphthalenes are known to form complexes with soil matter(5). The pKa of 2-naphthylamine is 4.16(6), indicating that this compound will partially exist in cation form in the environment.
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN1650 (For reference only, please check.) | IMDG: UN1650 (For reference only, please check.) | IATA: UN1650 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: beta-NAPHTHYLAMINE, SOLID (For reference only, please check.) | IMDG: beta-NAPHTHYLAMINE, SOLID (For reference only, please check.) | IATA: beta-NAPHTHYLAMINE, SOLID (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: II (For reference only, please check.) | IMDG: II (For reference only, please check.) | IATA: II (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: Yes | IMDG: Yes | IATA: Yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 2-naphthylamine | 2-naphthylamine | 91-59-8 | 202-080-4 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Do NOT take working clothes home.The substance may cause bladder cancer.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
2-Naphthylamine is included in Bulk Drug Intermediates category.
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