2-Nitrophenol Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 2-nitrophenol |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 2-nitro-1-hydroxybenzene; o-Nitrofenol; Phenol,o-nitro |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Intermediates |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Acute toxicity - Category 4, Inhalation
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H302 Harmful if swallowed H312 Harmful in contact with skin H332 Harmful if inhaled H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
| Response | P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P391 Collect spillage. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-nitrophenol | 2-nitrophenol | 88-75-5 | 201-857-5 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Inhalation or ingestion causes headache, drowsiness, nausea, and blue color in lips, ears, and fingernails (cyanosis). Contact with eyes causes irritation. Can be absorbed through the intact skin to give same symptoms as for inhalation. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Dinitrophenol and Related Compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources. Nitrophenols
5.2 Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic and irritating fumes of unburned material and oxides of nitrogen can form in fire. (USCG, 1999)
5.3 Special protective actions for fire-fighters
Use dry powder, carbon dioxide, water spray, alcohol-resistant foam.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers.
6.2 Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers.
6.3 Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Store in an area without drain or sewer access. Separated from strong oxidants, strong bases, strong acids and food and feedstuffs.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles.
Skin protection
Protective gloves.
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Solid. Needles or prismas. |
|---|---|
| Colour | Yellowish. |
| Odour | Peculiar, aromatic color |
| Melting point/freezing point | 44 °C. Atm. press.:1 013 hPa. |
| Boiling point or initial boiling point and boiling range | 214 °C. Atm. press.:1 013 hPa. |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 100.5 °C. Atm. press.:1 013 hPa. |
| Auto-ignition temperature | 485 °C. Atm. press.:1 013 hPa. Remarks:Temperature class: T1. |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | Miscible with water |
| Partition coefficient n-octanol/water | log Pow = 1.77. |
| Vapour pressure | 0.069 hPa. Temperature:20 °C.;0.2 hPa. Temperature:30 °C.;1 hPa. Temperature:50 °C. |
| Density and/or relative density | 1.495 g/cm³. Temperature:20 °C. |
| Relative vapour density | (air = 1): 4.81 |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides. Reacts with strong acids, strong bases and strong oxidants.
May explode on heating. On combustion, forms nitrogen oxides. Decomposes on heating. This produces toxic fumes including nitrogen oxides. Reacts with strong oxidants.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
AROMATIC NITROCOMPOUNDS ARE FLAMMABLE ... /AROMATIC NITROCMPD/Dust explosion possible if in powder or granular form, mixed with air.2-NITROPHENOL is a yellow, crystalline material, moderately toxic, low melting point (45° C). When heated to decomposition it emits toxic fumes of oxides of nitrogen. In molten form violent reaction with strong alkali (85% potassium hydroxide) [491 M, 1975, p. 342]. Reaction product with chlorosulfuric acid decomposes violently at room temperature [Vervalin, C. H., Hydrocarbon Proc., 1976, 55(9), p. 321].
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
The molten ortho-nitrophenol reacts violently with commercial 85% potassium hydroxide pellets. (possibly involving formation of the aci-o-nitroquinonoid salt).
10.6 Hazardous decomposition products
When heated to decomp it emits toxic fumes of /nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - > 3 200 mg/kg bw. Remarks:3/10 animals died at the highest dose.
- Inhalation: LC0 - rat - 0.22 mg/L air.
- Dermal: LD50 - rabbit - > 7 940 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is mildly irritating to the eyes and skin. Ingestion could cause effects on the blood. This may result in the formation of methaemoglobin.
STOT-repeated exposure
no data available
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - > 100 - <= 150 mg/L - 1 h.
- Toxicity to daphnia and other aquatic invertebrates: EC0 - Daphnia magna - 25 mg/L - 24 h.
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: More than 64 days were required to biodegrade 2-nitrophenol in an aqueous soil solution(1) however 2-nitrophenol was completely degraded in 7-14 days in a second soil inoculum(2). 2-Nitrophenol was mineralized 10% in a terrestrial ecosystem over the course of 10 days(3). 2-Nitrophenol, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(4). A half-life of about 37 days was observed for 2-nitrophenol in a laboratory batch microcosm incubated with sediment and groundwater(5). 2-Nitrophenol was degraded over 80% in an aerobic groundwater/sediment microcosm from a landfill during a 60 day incubation period(6). First-order rate constants of 0.01/day to 0.05/day were determined for 2-nitrophenol in aerobic aquifer material(7), corresponding to half-lives of about 14-69 days(SRC).
12.3 Bioaccumulative potential
BCF values of <2.2 to 5 were measured for carp (Cyprinus carpio) exposed to 1 ppm of 2-nitrophenol over a 6 week incubation period(1); BCF values of <22 were measured for carp exposed to 0.1 ppm 2-nitrophenol over a 6 week incubation period(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low.
12.4 Mobility in soil
The Koc of 2-nitrophenol in five reference European soils (pH 3.2-7.4) ranged from 32.1 to 265.7 with Koc generally decreasing with increasing pH(1); similar Koc values were determined for a second-generation set of five reference European soils(2). The Koc for 2-nitrophenol in Brookston clay loam was 114(3). In sorption studies using peat, 2-nitrophenol had measured Koc values of 85 (when 2-nitrophenol was in the neutral state) and 13 (when 2-nitrophenol existed as anionic species)(4). According to a classification scheme(5), a Koc range of 13 to 265 suggests that 2-nitrophenol is expected to have very high to moderate mobility in soil. The pKa of 2-nitropehnol is 7.23(6), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(7).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN1663 (For reference only, please check.) | IMDG: UN1663 (For reference only, please check.) | IATA: UN1663 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: NITROPHENOLS (o-, m-, p-) (For reference only, please check.) | IMDG: NITROPHENOLS (o-, m-, p-) (For reference only, please check.) | IATA: NITROPHENOLS (o-, m-, p-) (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: Yes | IMDG: Yes | IATA: Yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 2-nitrophenol | 2-nitrophenol | 88-75-5 | 201-857-5 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
2-Nitrophenol is included in Hair Dyeing category.
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