2-Nitrotoluene Safety Data Sheets

Acute toxicity - Category 4, Oral

Germ cell mutagenicity, Category 1B

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

Reproductive toxicity, Category 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

INHALATION, INGESTION, OR SKIN: Headache, flushing of face, dizziness, dyspnea (difficult breathing), cyanosis, nausea, vomiting, muscular weakness, increased pulse and respiratory rate, irritability, and convulsions. SKIN: Irritation. (USCG, 1999)

Special Hazards of Combustion Products: Toxic fumes may be generated. Behavior in Fire: Generates toxic fumes. (USCG, 1999)

Use water spray, powder, foam, carbon dioxide.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Ventilate area of spill or leak. For small quantities of liq nitrotoluene, absorb on paper towels. For small quantities of solid nitrotoluene, sweep onto paper or other suitable material. Remove to safe place (such as fume hood) & burn. Large quantities of liq nitrotoluene can be collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device. Large quantities of solid nitrotoluene can be reclaimed; ... If not practical, dissolve in flammable solvent (such as alcohol) & atomize in suitable combustion chamber equipped with appropriate effluent gas cleaning device. Nitrotoluene

NO open flames. NO contact with oxidizing agents. NO contact with incompatible materials: See Chemical Dangers Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs. See Chemical Dangers. Well closed. Ventilation along the floor. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Store in a cool. dry, well-ventilated location. Separate from acids, alkalies, oxidizing materials, and reducing agents.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on contact with strong oxidants, reducing agents, acids or bases. This produces toxic fumes. This generates fire and explosion hazard. Attacks some forms of plastic, rubber and coatings. On combustion, forms nitrogen oxides and carbon monoxide.

Heat contributes/ ... to instability. Nitrotoluene

Comubstible when exposed to heat or open flame.O-NITROTOLUENE is toxic by inhalation, ingestion and skin aborption, targeting the blood, central nervous system, skin, and gastrointestinal tract. Symptoms include, anoxia, weakness or dizziness, nausea and vomiting. If it contacts the eye, the eye should be irrigated immediately. If it contacts the skin, the area should be washed with soap. If inhaled, respiratory support should be administered. Finally, if ingested, medical attention should be sought. It also reacts with sulfuric acid, sodium hydroxide, hydrogen, sodium, tetranitromethane, reducing agents and strong oxidizers. It is very heat sensitive.

no data available

Decomposes on contact with strong oxidzers; strong acids; reducing agents; strong bases; ammonia, amines producing toxic fumes, causing fire and explosion hazard. Heat above 190 deg C may cause explosive decomposition. Attacks some plastics, rubbers, and coatings.

The substance decomposes ... /to/ form nitrogen oxides, carbon monoxide.

Acute toxicity

• Oral: LD50 - rat (male/female) - ca. 2 100 mg/kg bw.
• Inhalation: LC50 - rat (male) - > 1.086 mg/L air.
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - 40 mg/L - 7 d.
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 5.4 mg/L - 48 h.
• Toxicity to algae: EC50 - Chlorella pyrenoidosa - 22 mg/L - 72 h.
• Toxicity to microorganisms: toxic threshold (EC5) - Entosiphon sulcatum - 46 mg/L - 72 h.

AEROBIC: 2-Nitrotoluene, present at 100 mg/L, reached 0.5% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese Ministry of Industry and Trade (MITI) test that employs a mixed inoculum obtained from freshwater, soil, and sludge(1). Other evidence supports complete aerobic degradation of 10 mg/L 2-nitrotoluene within 2 weeks when incubated in adapted aerobic composite river sediment and sewage sludges(3). When nitrotoluene-adapted activated sludges were used as an inoculum, however, 2-nitrotoluene (200 mg/L) was almost completely degraded (i.e. 98% removal) within 5 days when incubated at 20 deg C(3). The screening studies using unadapted sludges gave similar results as the MITI test, and 2-nitrotoluene is confirmed to be non biodegradable according to the standard MITI test. Using a mixed culture isolated from a contaminated soil (near an ammunition plant), 2-nitrotoluene (at initial concentrations of 3.5 mg/L) degraded completely in 8 days in aerobic batch and continuous reactor tests(4).

The BCF for 2-nitrotoluene has been measured to be 12.5-29.9 (at a concentration of 0.1 ppm) and 6.6-29.7 (at 0.01 ppm) in carp (Carprinus carpio)(1). An estimated BCF of 15 was calculated for 2-nitrotoluene(SRC), using a log Kow of 2.30(2) and a regression-derived equation(3). According to a classification scheme(4), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2-nitrotoluene can be estimated to be 370(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-nitrotoluene is expected to have moderate mobility in soil. Field monitoring at a munition factory site in Melbourne Australia found that 2-nitrotoluene migrated large distances in the subsurface soils(3); 2-nitrotoluene is reported to have low soil Kd sorption coefficients in a variety of soils types(3) indicating it will leach.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Specific treatment may be necessary in case of poisoning with this substance; the appropriate means with instructions should be available.Do NOT take working clothes home.Depending on the degree of exposure, periodic medical examination is suggested.