Amyl acetate Safety Data Sheets

Flammable liquids, Category 3

If inhaled

Following skin contact

Following eye contact

Following ingestion

Irritation of eyes, nose and throat. Dizziness, nausea, headache. (USCG, 1999)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

Use alcohol-resistant foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

1) Remove all ignition sources. 2) Ventilate area of spill or leak. 3) For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber. n-Amyl acetate should not be allowed to enter confined space, such as a sewer, because of the possibility of explosion.

NO open flames, NO sparks and NO smoking. Above 25°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from oxidants.Storage temp: ambient (cool)

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Reacts with oxidants. This generates fire and explosion hazard. Attacks many plastics.

Stability during transport: stable

Dangerous fire hazard when exposed to heat or flame .The vapour is heavier than air.AMYL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This compound is incompatible with the following: Nitrates; strong oxidizers, alkalis & acids (NIOSH, 2016).

no data available

Nitrates; strong oxidizers, alkalis and acids.

When heated to decomposition it emits acrid smoke and irritating fumes.

Acute toxicity

• Oral: LD50 Rat female oral 17250 mg/kg bw Primary Amyl Acetate (mixed isomers): 65% 1-pentyl acetate and 35% 2-methyl-1-butyl acetate
• Inhalation: LC50 Rat male inhalation >5200 ppm (27664 mg/cu m)/4 hr Primary Amyl Acetate (mixed isomers): 65% 1-pentyl acetate and 35% 2-methyl-1-butyl acetate
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: no data available
• Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water Flea) age < or =24 hr; Conditions: freshwater, static, 20-22 deg C; Concentration: 210000 ug/L for 24 hr /formulation
• Toxicity to algae: LC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 1300000 ug/L for 24 hr /formulation
• Toxicity to microorganisms: no data available

AEROBIC: Two screening tests gave 13 and 38% of theoretical BOD values after 5 days(1). The first test used sewage seed and 1.7-20 ppm of n-amyl acetate and the second test used 440 ppm of the chemical and 10% sewage seed(1). In a biodegradability screening test using non-acclimated sewage seed, the 5 day biological oxygen demand value for n-amyl acetate was 64 and 35% theoretical in fresh and salt water(2). After 20 days the respective values were 72 and 87%(2). The degradation kinetics of n-amyl acetate in Lake Superior harbor water was first order(3). When the water was coarsely filtered (suspended solids 5.6 mg/L), the biodegradation half-life was 10.0 days, when the water was finely-filtered (2.5 mg/L suspended solids), the half-life was 4.5 days(3). The increase in rate using finely-filtered water was attributed to the reduced level of suspended solids since the other water characteristics were comparable, no reason was offered for why this might increase the biodegradation rate(3). Using a standard BOD dilution technique and an acclimated mixed culture inoculum, a theoretical BOD of 31% was observed over a 5-day incubation period(4). Using the same test with an activated sludge inoculum, a theoretical BOD of 23% was observed over a 5-day incubation period(5). The theoretical BOD for n-amyl acetate in river water over a 20-day incubation period was 50%(6).

An estimated BCF of 15 was calculated in fish for n-amyl acetate(SRC), using a log Kow of 2.3(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of n-amyl acetate can be estimated to be 34(SRC). According to a classification scheme(2), this estimated Koc value suggests that n-amyl acetate is expected to have very high mobility in soil.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Use of alcoholic beverages enhances the harmful effect.