Benzylamine Safety Data Sheets

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin corrosion, Sub-category 1B

If inhaled

Following skin contact

Following eye contact

Following ingestion

Inhalation of vapor causes irritation of the mucous membranes of the nose and throat, and lung irritation with respiratory distress and cough. Headache, nausea, faintness, and anxiety can occur. Exposure to vapor produces eye irritation with lachrymation, conjunctivitis, and corneal edema resulting in halos around lights. Direct local contact with liquid is known to produce severe and sometimes permanent eye damage and skin burns. Vapors may also produce primary skin irritation and dermatitis. (USCG, 1999)

Special Hazards of Combustion Products: Toxic nitrogen oxides may form in a fire. (USCG, 1999)

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize remainder. Then wash away with plenty of water.

Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize remainder. Then wash away with plenty of water.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

NO open flames, NO sparks and NO smoking. Above 60°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from strong oxidants, strong acids and food and feedstuffs.Fireproof. Separated from strong oxidants, strong acids, food and feedstuffs.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on burning. This produces toxic fumes including nitrogen oxides. The substance is a medium strong base. Reacts with acids and strong oxidants.

no data available

FlammableIn presence of moisture, BENZYLAMINE may weakly corrode some metals. Liquid will attack some plastics (USCG, 1999). Neutralize acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

no data available

Violent or explosive reaction with N-chlorosuccinimide

When heated to decomposition it emits toxic fumes.

Acute toxicity

• Oral: LD50 - rat (male/female) - 563 mm³/kg bw. Remarks:Corresponding to 552 mg/kg bw.
• Inhalation: LC50 - rat (male/female) - > 0.4 mg/L air (nominal).
• Dermal: LD50 - rat (male) - ca. 1.35 g/kg bw.

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Leuciscus idus - > 21.5 - < 46.4 mg/L - 96 h.
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 100 mg/L - 48 h.
• Toxicity to algae: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 50 mg/L - 72 h.
• Toxicity to microorganisms: IC50 - Tetrahymena pyriformis - 186 mg/L - 40 h.

AEROBIC: Benzylamine, present at 100 mg/L, reached an average 63.5% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). The results of different screening tests indicate that benzylamine is readily biodegradable(2); the test and results are as follows(3): Coupled Units test: 101% DOC removal; Zahn-Wellens test: 96% DOC removal after 4 days; Sturm test: 90% CO2 evolution; OECD Screening test: 96% DOC removal; Closed Bottle test: 30-day theoretical BOD of 53% using modified procedures(1). Using the Zahn-Wellens test, a degradation in excess of 90% was observed over a six-day incubation period(3). Biomineralization of benzylamine was measured (via 14-CO2 evolution) in sediment taken beneath a laundromat waste-water pond and a pristine control pond(4); benzylamine was rapidly degraded in both sediments without a lag period(4); depending upon depth of sediment, the mineralization rate constant ranged from 0.096 to 0.313 per day(3); the mean half-life was 3.3 days(3). Concentrations of 500 mg/L benzylamine were toxic to microorganisms in Warburg respirometer studies using activated sludge inocula(5,6).

An estimated BCF of 2.4 was calculated for benzylamine(SRC), using a log Kow of 1.09(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of benzylamine is estimated as 270(SRC), using a log Kow of 1.09(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that benzylamine is expected to have moderate mobility in soil. The pKa of benzylamine is 9.33(4), indicating that this compound will almost entirely exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation is therefore essential.Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.