Chlortoluron Safety Data Sheets

Carcinogenicity, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

Reproductive toxicity, Category 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

no data available

Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

Use water spray, foam, dry powder, carbon dioxide.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder.

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. Separated from strong bases, strong acids and food and feedstuffs.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

On combustion, forms toxic fumes. Reacts with strong acids and strong bases.

Stable under normal conditions in neutral media. Hydrolyzed by strong acids and alkalis.

On combustion, forms toxic fumes. Reacts with strong acids and strong bases.

no data available

no data available

no data available

Acute toxicity

• Oral: LD50 Rat oral greater than 10000 mg/kg
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: no data available
• Toxicity to daphnia and other aquatic invertebrates: no data available
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

Degradation of chlortoluron proceeds through the cleavage of the C-N bond as demonstrated using both soil and microbial culture studies(1). Chlortoluron had a half-life in soil of 4-6 weeks(2). The only metabolite identified in this study was monomethyl chlortoluron(2). A half-life of between 6-18 weeks was reported for chlortoluron(3). In biometer experiments, half-lives of 93 days and 40 days were measured for chlortoluron in a silty sand and silty loam soil, respectively(4). However, the disappearance of this compound in an outdoor lysimeter experiment was slower in silty loam (49 days, fallow land; 38 days, barley field) than in silty sand(52 days, fallow land; 14 days, barley field)(4). The main metabolite of chlortoluron degradation was N-dimethylated chlortoluron(4). Chlortoluron, applied as either a suspendible concentrate or wettable powder, had a calculated half-life of 96 days for both conditions in one soil (pH 5.1; organic carbon 4.1%; silt 16%; water holding capacity 27%); a second soil (pH 7.0; organic carbon 1.6%; silt 11% water holding capacity 16.6%) had calculated half-lives of 82 and 84 days for a suspendible concentrate and wettable powder, respectively(5).

An estimated BCF value of 40 was calculated for chlortoluron(SRC), using an experimental log Kow of 2.41(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme, this BCF value suggests that bioconcentration in aquatic organisms is moderate, not high(3). Winter wheat grown in soil containing 4.7 mg chlortoluron/kg dry soil had bioconcentration factors of 21 and 22 for root material and for shoots, respectively (bioconcentration factor is the concentration of 14C from the chlortoluron in the plant versus the soil)(4).

An average organic matter-water distribution of 60 was measured for seven soils (organic matter range 1.09-5.92%; pH range 5.9-7.5)(1). Seventeen soils from Australia had a range of organic matter-water distribution values for this compound from 25-85, giving Koc values ranging from 1-3467 (organic matter range 0.19-6.62; pH range 4.8-8.4)(2). Leaching was studied following field application of chlortoluron to a sandy soil; after 10 cm of rain had fallen, >2 mg/kg, 1 mg/kg, 0.5 mg/kg, and a trace remained in the 0-2.5, 2.5-5, 5-7.5, and 7.5-10 cm depth, respectively(2). Chlortoluron has measured Koc values ranging from 146-346 for eight Czechoslovakian soils (mean=228), with higher values corresponding to soils with a greater content of organic matter(3). Koc values of 271 and 419 were measured for a loamy sand and a mucky peat soil, respectively, at 25 deg C(4). According to a recommended classification scheme(5), these estimated Koc values suggest that chlortoluron has moderate mobility in soil(SRC). Adsorption of chlortoluron corresponds to an L-isotherm indicating that as the solution concentration increases, there is a decrease in site availability(6). Chlortoluron, applied at a rate of 2.0 kg/ha to sandy soil monoliths containers, had a measured Koc of 160 and 113 in the A and B horizons, respectively(7). The addition of liquid manure, increasing the organic carbon content, resulted in reduced mobility(7).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Tumors of kidney and liver were observed at high dose levels in mice.The substance is combustible but no flash point is available in literature.