Ethylenethiourea Safety Data Sheets

Acute toxicity - Category 4, Oral

Reproductive toxicity, Category 1B

If inhaled

Following skin contact

Following eye contact

Following ingestion

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes Target Organs: Eyes, skin, thyroid, reproductive system (NIOSH, 2016)

This chemical is combustible. (NTP, 1992)

Use water spray, powder, foam, carbon dioxide.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

NO open flames. PREVENT DISPERSION OF DUST. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants. Store in an area without drain or sewer access.Store in tightly closed containers in a cool, well ventilated area away from strong oxidizers, acids, acid anhydrides, acrolein. Store in a refrigerator or a cool, dry place. A regulated marked area should be established where this chemical is handled, used, or stored ...

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

NIOSH considers ethylene thiourea to be a potential occupational carcinogen.

Decomposes on heating and on burning. This produces toxic and irritating fumes including nitrogen oxides and sulfur oxides. Reacts with strong oxidants. This generates fire and explosion hazard.

no data available

Dust explosion possible if in powder or granular form, mixed with air.ETHYLENE THIOUREA may be sensitive to prolonged exposure to light. Incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. May react with acids to liberate hydrogen sulfide.

no data available

Strong oxidizers, acids, acid anhydrides, acrolein.

When heated to decomposition it emits very toxic fumes of /nitroxides/ and /sulfoxides/.

Acute toxicity

• Oral: LD50 Rat oral 545 mg/kg bw
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: EC50; Species: Oncorhynchus mykiss (Rainbow trout, fertilized egg- early fry stage); Conditions: freshwater, renewal, 10 deg C, pH 7.7, hardness 50 mg/L CaCO3; Concentration: 1000000 ug/L for 60 days (95% confidence interval: 600000-3200000 ug/L); Effect: morphological abnormalities /> or =99% purity
• Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea); Conditions: freshwater, renewal; Concentration: 26400 ug/L for 48 hr (95% confidence interval: 21600-32200 ug/L) /99% purity
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: Ethylene thiourea was found to be readily degraded by soil microorganisms(1). Ethylene thiourea degraded rapidly in soil to ethyleneurea and then CO2; however, studies with autoclaved soil indicated that initial conversion was accomplished chemically(2) while further degradation to CO2 was accomplished microbially(3). Ethylene thiourea was shown to be biodegradable in aerobic soil samples from a sandy locality in western Jylland, Denmark at a concentration 125 ug/L incubated in the dark at 23 deg C for 120 days(4). Aerobic decay rates were 11.4 to 13.3 ug/kg soil-day(4). Degradation of 0.07 mg/kg 14C-labeled ethylene thiourea was determined in surface (19% in 24 hrs) coarse sandy field soil from Denmark(5). Subsurface rates were affected by soil depth; 16% and 23% at 100 and 60 cm depth, respectively, after 109 days. Following a 5 day incubation of 0.05 mg/L ethylene thiourea in activated sludge, 2.9% of applied amount was degraded(5). Ethylene thiourea, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(6).

BCFs of <0.2 to 0.3 and <1.8 were determined in carp (Cyprinus carpio) for ethylene thiourea at concentrations of 1.0 and 0.1 ppm exposed for 6 weeks(1). According to a classification scheme(2), these BCFs suggest bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of ethylene thiourea can be estimated to be 13(SRC). According to a classification scheme(2), this estimated Koc value suggests that ethylene thiourea is expected to have very high mobility in soil. Average Rf values of 0.96 (Norfolk sandy loam), 1.00 (Lakeland sandy loam), 0.96 (Hagerstown silty clay loam), 0.83 (Barnes clay loam) and 0.61 (Celeryville muck) were measured using soil TLC plates which is indicative of high mobility in all the soils except the muck which has intermediate mobility(3). Ethylene thiourea Kd values were measured in Dutch soils from Fladerne Baek, March 1994; 0.06 (2.1% clay, 1.4% silt, 96.3% sand, 0.1% humus, pH 6.4), 0.13 (2.5% clay, 1.4% silt, 95.7% sand, 0.3% humus, pH 6.3), 0.17 (3.6% clay, 2.8% silt, 90.8% sand, 2.8% humus, pH 6.9)(4).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.