N-Nitrosodimethylamine Safety Data Sheets

Acute toxicity - Category 3, Oral

Acute toxicity - Category 2, Inhalation

Carcinogenicity, Category 1B

Specific target organ toxicity – repeated exposure, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: nausea, vomiting, diarrhea, abdominal cramps; headache; fever; enlarged liver, jaundice; decreased liver, kidney, pulmonary function; [Potential occupational carcinogen] Target Organs: Liver, kidneys,lungs Cancer Site [in animals; lung, kidney, liver & nasal cavity tumors] (NIOSH, 2016)

When heated to decomposition, it emits toxic fumes of nitrogen oxides. Avoid exposure to ultraviolet light. (EPA, 1998)

Use powder, carbon dioxide.

Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Spills of n-nitrosodiethylamine can be absorbed by celite or commercial spill absorbant. after absorbant containing major share of nitrosamine has been picked up (avoid dusts; do not sweep), surface should be thoroughly cleaned with strong detergent soln. if major spill occurs outside of ventilated area, room should be evacuated & cleanup operation should be carried out by persons equipped with self-contained respirators. those involved in this operation should wear rubber gloves, lab coats, & plastic aprons or equivalent protective apparel. n-nitrosodiethylamine, also applicable to other dialkylnitrosamines

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants and food and feedstuffs. Cool. Keep in the dark. Well closed.ALL BOTTLES OF N-NITROSODIETHYLAMINE SHOULD BE STORED & TRANSPORTED WITHIN UNBREAKABLE OUTER CONTAINER; STORAGE SHOULD BE IN VENTILATED STORAGE CABINET (OR IN HOOD). N-NITROSODIETHYLAMINE, ALSO APPLICABLE TO OTHER DIALKYLNITROSAMINES

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

NIOSH considers N-nitrosodimethylamine to be a potential occupational carcinogen.

Decomposes on heating. This produces nitrogen oxides. Reacts with strong oxidants and strong bases.

Stable at room temperature for more than 14 days in neutral or alkaline solutions in the dark; slightly less stable in acidic solutions; sensitive to UV light.

CombustibleN-NITROSODIMETHYLAMINE is sensitive to exposure to light, especially ultraviolet light. Is stable at room temperature for more than 14 days in aqueous solution at neutral and alkaline pH in the absence of light. Slightly less stable at strongly acid pH at room temperature. Incompatible with strong oxidizing agents. Also incompatible with strong bases. Can be reduced by reducing agents. Incompatible with hydrogen bromide in acetic acid. Also photochemically reactive. (NTP, 1992)

no data available

Oxidants, especially peracids. Sensitive to UV light.

When heated to decomp it emits toxic fumes of /oxides of nitrogen/.

Acute toxicity

• Oral: LD50 Rat oral 27-41 mg/kg
• Inhalation: LC50 Rat inhalation 78 ppm/4 hr
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LD50; Species: Oncorhynchus mykiss (Rainbow trout) ip 1770 mg/kg for 10 days
• Toxicity to daphnia and other aquatic invertebrates: no data available
• Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae) 10000 cells; Conditions: freshwater, static, 24 deg C; Concentration: 5100 ug/L for 96 hr; Effect: growth, general
• Toxicity to microorganisms: no data available

No biodegradation of dimethylnitrosamine was observed in lake water samples during an observation period of 3.5 months, and a lag of nearly 30 days occurred before its slow disappearance from soil. The nitrosamine appeared to be degraded very slowly in sewage, but it was not affected by the anaerobic organisms /found in collected bog sediments/.

An estimated BCF of 3 was calculated in fish for N-nitrosodimethylamine(SRC), using a log Kow of -0.57(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).

Kd (soil distribution coefficient) values of 0.45-0.64 L/kg were measured for N-nitrosodimethylamine in turfgrass, ground cover and bare surface soils that corresponded to Koc values 68-118(1). Similar results were observed in a study of subsurface soil samples including sand, sandy loam and loamy sand soils with Kd values ranging from 0.4-1.2 L/kg(2). According to a recommended classification scheme(3), the Koc values suggests that N-nitrosodimethylamine is expected to have high mobility in soil(SRC). N-Nitrosodimethylamine was found to leach through 4 different soils as readily as chloride ion(4). Another study also found that N-nitrosodimethylamine readily leached through soils(5). The leaching risk of N-nitrosodimethylamine in soils receiving reclaimed wastewater depend upon the hydraulic conductivity of the soil and irrigation intensity(6); proper irrigation volumes can reduce the leaching risk(6).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

The symptoms of jaundice do not become manifest until some hours have passed.TLV Note: Exposure by all routes should be carefully controlled to levels as low as possible.