2-Chlorophenol Safety Data Sheets

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Acute toxicity - Category 4, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. Irritating to skin and eyes; direct contact may cause burns. Rats receiving lethal doses via oral, subcutaneous or intraperitoneal routes displayed similar symptoms: restlessness, increased breathing rate and motor weakness followed by tremors, chronic convulsions, dyspnea, coma and death. (USCG, 1999)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Special Hazards of Combustion Products: Contain poisonous chloride fumes. Behavior in Fire: Burns and produces toxic and irritating gases. (USCG, 1999)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Carefully collect remainder. Then store and dispose of according to local regulations.

Phenolic cmpds in wastewater are oxidized with hydrogen peroxide catalyzed by iron(3+)-iron(2+) When the wt ratio of phenol:hydrogen peroxide is 1:3 and iron 5-100 ppm, more than 95% of the phenols are removed in 30 min from a 500 ppm phenol soln at pH 5-6 and 25-50 deg C. Phenolic cmpd

NO open flames. Above 64°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants and food and feedstuffs. Well closed.Store in tightly closed containers in a cool, well ventilated area. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to precess containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Monochlorophenols

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on burning. This produces toxic and corrosive fumes of hydrochloric acid and chlorine. Reacts with oxidants.

no data available

Combustible liquid.The vapour is heavier than air.2-CHLOROPHENOL is a weak acid. Neutralizes bases in exothermic reactions. Incompatible with oxidizing agents. Incompatible with acid chlorides and acid anhydrides. Forms ethers, esters and salts with metals and amines (NTP, 1992).

no data available

Can react with oxidizing materials

When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

Acute toxicity

• Oral: LD50 Rat oral 670 mg/kg. From table
• Inhalation: LC50 - rat (male/female) - >= 4.77 mg/L air (analytical).
• Dermal: LD50 - rat (male/female) - > 1 000 - < 1 580 mg/kg bw.

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50; Species: Danio rerio (Zebra danio, length 2.5 cm); Conditions: freshwater, static, 22 deg C, pH 7.8-8, hardness 150 mg/L CaCO3; Concentration: 35000-100000 ug/L
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 5.7 mg/L - 48 h.
• Toxicity to algae: EC100 - Chlorella pyrenoidosa - 500 mg/L - 72 h.
• Toxicity to microorganisms: no data available

AEROBIC: 2-Chlorophenol, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum(1). In an aerobic screening test, the microorganism Pseudomonas gladioli was able to degrade 2-chlorophenol 74.6% after an incubation period of 24 hours and an initial concn of 8.78 ug/ml(2). 2-Chlorophenol was 100% degraded by a microbial mixture inoculum after an incubation time of 96 hours(3). The aerobic biodegradation of 2-chlorophenol in the cyclone fermentor system revealed 0% remaining after 200 hours and a lag time of 25 hours; this corresponds to a half-life of 140 hours(4). Incubation at 30 deg C resulted in incomplete removal of 2-chlorophenol, which ceased after 48 hours. 64.8% of 2-chlorophenol was removed; however, only 30.2% of the total chloride was released. Degradation proceeded via meta-cleavage and a build-up of the metabolite 3-chlorocatechol was observed(5). 2-Chlorophenol reached 38.0% of its theoretical BOD in river water obtained from the Jilin section of the Songhua River, China. A test concn of 2 mg/L (based on the Theoretical Oxygen Demand for 2-chlorophenol) was tested at 15-20 deg C, pH 6.8-7.0, and a dissolved oxygen concn of 8.0 mg/L using standard iodometric tritration(6).

BCF's of 214 (log BCF = 2.33) in bluegill sunfish after 28 days exposure(1), 14 to 29 in carp(2), and 6 for goldfish(3) were determined for 2-chlorophenol. According to a classification scheme(4), BCF values of zero to 30 are low and from 100 to 1,000 are high.

Experimentally determined Koc's for 2-chlorophenol in various soil conditions were reported as 51 in clay loam soil and 398 in unspecified soil(1). Koc values of 3,981 in coarse sediment, and 5,012 in fine sediment have also been reported(1). According to a classification scheme(2), 2-chlorophenol will exhibit high to moderate mobility depending on soil type(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation is therefore essential.Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.