ACS Med. Chem. Lett. | first not two aromatic amine MEK - PROTAC protein JiangXieJi P6b
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Recently, Professor Xu Ping's research group of Peking University reported the first non-diarylamine MEK-PROTAC protein degrader P6b in the Journal.
1. Targets and indications
◆ Target: MEK1/2 protein
◆ Indications: a variety of cancers
2. Biological activity
In A549 cells, P6b efficiently degraded MEK1/2 protein with DC50 of 0.29 μM and 0.2 μM, respectively.
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