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Home > News > Market Flash > ACS Med. Chem. Lett. | first not two aromatic amine MEK - PROTAC protein JiangXieJi P6b

ACS Med. Chem. Lett. | first not two aromatic amine MEK - PROTAC protein JiangXieJi P6b

yaozh.com 2023-05-16

Focus on the most cutting-edge research results in the field of protein degradation and catch the latest developments in the PROTAC market? It's all in the five-minute "Today's PROTAC Headlines" series of tweets from Minox's ReThinking PROTAC platform.

Recently, Professor Xu Ping's research group of Peking University reported the first non-diarylamine MEK-PROTAC protein degrader P6b in the Journal.

1. Targets and indications
◆ Target: MEK1/2 protein
◆ Indications: a variety of cancers

2. Biological activity
In A549 cells, P6b efficiently degraded MEK1/2 protein with DC50 of 0.29 μM and 0.2 μM, respectively.

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