The Top 15 Generic Drugmakers by 2016 Revenue

Branded drugmakers weren't the only ones working through a tumultuous 2016. Generics companies faced pricing pressure, too. And while branded companies suffer pricing pain on costly cutting-edge therapies, generics outfits feel the pinch with already-thin margins, making pressure all the more agonizing.

How is the industry responding? By consolidating and hoping to save money, for one. Take a look at FiercePharma's 2014 ranking, and it's clear that some companies have made leaps too big to depend on organic growth alone.

Take Teva, which topped the 2016 list as it did in 2014. It wrapped up the biggest M&A move in recent history for the generics industry, swallowing Allergan’s unbranded offerings for $40.5 billion in August. The massive move will continue to reverberate in the generics industry for years to come.

Behind Teva came Mylan, which also completed a big deal last year, a $7.2 billion buyout of Sweden’s Meda. The buy helped it bulk up in over-the-counter drug offerings and win a presence in some emerging markets new to the U.S.-based company. That acquisition followed a series of others in recent years, and Mylan is now working to cut loose up to 3,500 employees as it aims to reap savings from that deal spree.

Trailing those two companies was Novartis, whose Sandoz unit tallied $9 billion in off-brand sales for the year, according to life science commercial intelligence firm Evaluate.

From there, the industry saw a bit of a dropoff: Pfizer came in fourth with $4.6 billion, while Allergan, which officially offloaded its generics assets in August, rounded out the top 5 with $4.5 billion. Other names in the top 15 are familiar to industry watchers: Sun Pharmaceutical Industries, Fresenius, Endo International, Lupin, Sanofi, Aspen Pharmacare, Aurobindo, Cipla, Apotex and Dr. Reddy’s Laboratories.

If pricing pressure alone was not enough of a challenge for the generics industry, multiple top players are also embroiled in a pricing collusion probe at the Department of Justice, an issue that could weigh on the sector going forward. Several have been slapped by the FDA for manufacturing violations that continue to weigh on their ability to supply key meds.