One of The Safe Weight Loss Tablets - Orlistat

At present, obesity has become a public health problem all over the world. The International Obesity Task Force pointed out that obesity will become the biggest killer of human health and life satisfaction in the new century. It is undeniable that obesity has become a cause of some diseases, and even has become a disease, and has been a serious threat to our health. At present, drugs with good weight loss effect in clinical use in China include semaglutide, liraglutide, orlistat, metformin, etc. Combining all the large-scale high-evidence studies and clinical experience now, the most effective is the orlistat capsule. Orlistat capsules are considered to be safe and less side effects weight loss pills, called "oil discharge pill" on the Internet, and is the only approved over-the-counter weight loss pills in China, So is it a really safe weight loss tablet?

Pharmacological principle

Orlistat is considered one of safe weight loss tablets because it is a long-acting and potent specific inhibitor of gastrointestinal lipase, which interacts with gastric lipase and pancreatic lipase activity in the lumen of the stomach and small intestine. The serine site forms a covalent bond to inactivate the enzyme and exert a therapeutic effect. Inactive enzymes are unable to hydrolyze dietary fats into absorbable free fatty acids and monoacylglycerols. Undigested triglycerides cannot be absorbed by the body, thereby reducing caloric intake and controlling weight. To put it simply, the fat ingested by the human body is broken down into small molecules in the intestine to be absorbed to make the human body gain weight, and orlistat achieves weight loss by preventing this process.

Indications

Orlistat Capsules combined with a low-calorie diet is suitable for the long-term treatment of obese and overweight patients, including those patients who have developed obesity-related risk factors. Orlistat capsules have long-term weight management (weight loss, weight maintenance, and rebound prevention) effects. Taking orlistat capsules reduces risk factors associated with obesity and the incidence of other obesity-related diseases, including hypercholesterolemia, type 2 diabetes, impaired glucose tolerance, hyperinsulinemia, hypertension, and Reduce the fat content in the organs.

Adverse reactions

Orlistat, like other safe weight loss tablets, has certain side effects. Orlistat capsules mainly cause gastrointestinal adverse reactions, which are related to the pharmacological action of the drug to prevent the absorption of ingested fat. Common adverse reactions are: oily spots, increased gastrointestinal flatulence, stool urgency, fatty (oily) stools, steatorrhea, increased stool frequency and fecal incontinence. These gastrointestinal adverse reactions are usually mild and transient, they appear in the early stage of treatment (the first 3 months), and most patients have only a transient adverse reaction. The most common acute gastrointestinal reactions in patients taking orlistat capsules are: abdominal pain/abdominal discomfort, flatulence, watery stools, soft stools, rectal pain/rectal discomfort, dental discomfort, gum discomfort . Other rare adverse events observed were: upper respiratory tract infection, lower respiratory tract infection, influenza, headache, menstrual disorders, anxiety, fatigue, urinary tract infection. Occasionally allergic reactions to this product have been reported, and the main clinical manifestations are pruritus, rash, urticaria, angioedema, and allergic reactions. Rarely, there have been case reports of bullous herpes, elevated liver transaminases and alkaline phosphatase, and rare hepatitis.

Precautions

After up to two years of orlistat treatment, the majority of patients had vitamin A, E, K, and beta carotene levels within normal ranges. To ensure adequate nutrients, consider taking a multivitamin supplement. Patients should be educated to follow dietary guidelines. The likelihood of gastrointestinal events was increased when orlistat capsules were co-administered with a high-fat diet. Obese patients with type 2 diabetes who lose weight after taking orlistat are often accompanied by improved blood sugar control, and need to adjust hypoglycemic drugs to avoid hypoglycemia.

Summary

Although orlistat is the number one safe weight loss tablet, if you just want to eat orlistat to achieve weight loss, its effect is very weak. Of course, other drugs known as safe weight loss tablets should not be taken indiscriminately. All in all, orlistat is a relatively safe one compared to other micro-commercial products with No name, No address, No production and sanitation license code, but when taking this product, you should try to reduce the intake of foods with high fat content, and you should pay attention to combining exercise and diet control in order to achieve good results. The instructions should be read carefully before use, and the drug should be used reasonably according to the instructions to treat obesity and overweight. When symptoms related to serious adverse reactions occur, you should seek medical attention in time, and take effective risk management measures to minimize the occurrence of adverse reactions.