New Technology In Pharmacy: Artificial Intelligence Senses

This new technology in pharmacy includeselectronic tongue, electronic nose, electronic eye, etc. The following willintroduce the types of this new technology in pharmacy, in order to provide othernew technology in pharmacy to solve related problems.

Electronic tongue, also known astaste sensor, is a new multi-sensor detection system that uses tastefingerprint analysis technology to simulate human taste organs to analyze andidentify the "taste" of liquid.

Application of electronic tongue inthe field of pharmacy

1. Identificationof Traditional Chinese Medicine

The taste of traditional Chinesemedicine is an important characteristic of Chinese medicinal materials, but thedescription of the taste of traditional Chinese medicine by people isrelatively vague and subjective, while the electronic tongue can objectivelyrepresent the taste of traditional Chinese medicine. The detection results oftraditional Chinese medicines are modeled, the common characteristics of knownsamples are found, and the common taste spectrum is extracted.

2. Distinguishingbetween different flavors of medicines

The electronic tongue sensor cansimulate the structure of taste buds in the oral cavity, and can produce tastesensation to taste molecules. Its cavity-like sensor structure and chemicalselection area simulate the reaction of organic lipid biofilms to substances,thus playing the role of simulating taste buds, which can be used for drugs.Different tastes of medicines can be distinguished, and different tastes ofmedicines can be compared, which can quickly and effectively test and screen alarge number of candidate formulations, develop and select products that meetconsumer tastes, and avoid repeated development processes or unpopularproducts. Based on this technology, the absolute bitterness of new molecularentities can also be predicted, so as to select the best new molecular entitiesand corresponding formulations to develop formulations.

Electronic nose, also known as odorfingerprint technology, originated in the 1980s, is a device with the abilityto identify single or complex gases composed of multiple gas sensors withoverlapping properties and appropriate pattern classification methods.

Application of electronic nose inthe field of pharmacy

1. Identificationof Traditional Chinese Medicine

Artificial intelligence sensorytechnologies such as electronic noses inherit the advantages of controlling thequality of traditional Chinese medicines as a whole. At the same time, combinedwith modern analysis methods, they can meet the needs of modern standardizedcontrol of traditional Chinese medicines, and can analyze, identify and detectcomplex odors and volatile components to identify medicinal materials.

2. Developmentof Placebo

The design of clinical trials ofdrugs mostly follows the four principles of randomization, control, blinding,and repetition. In the process of implementing the blinding principle, theplacebo as a control is required to be consistent with the therapeutic drug inappearance, color, and smell, and cannot be used for clinical trials. Thediseases treated in the trial have pharmacological activity, so the placebo isusually made of starch, glucose, saline, etc. into tablets, capsules, injections,etc., and it is not difficult to make placebos in these dosage forms. But fortraditional Chinese medicine, such as decoction and powder, due to the uniquesmell and color of traditional Chinese medicine, it is difficult toartificially simulate and produce a reference substance similar to itsappearance and smell. At this time, the participation of electronic nose orelectronic tongue is required to Completed placebo test.

The electronic eye can be called anintelligent vision sensor, which has the functions of image acquisition,digital image processing and result feedback. They have regained their sight;in the field of security monitoring: illegal monitoring of vehicle informationto facilitate post-accident processing; in the field of industrial visualinspection: quality control and analysis of products.

Application of electronic eye inthe field of pharmacy

1. DrugQuality Control

Sandadi et al. developed a digitalimaging system similar to an electronic eye to analyze the surface of tumblingtablets in a cartridge in real time. For 3 different size tablets, the cycletime and surface exposure time were explored in different processes. Mixing oftablet and coating excipients conditions, it was found that the required cycletime and surface exposure time showed the same trend of increasing withincreasing roller speed and increasing tablet size. Ketterhagen et al. furtherapplied the discrete element method to study the influence of three factors oftablet shape, speed and loading on the coating uniformity, but in a case basedon the data first measured by the machine vision inspection system As a kind ofelectronic eye, machine vision also shows that its application in the field ofpharmaceuticals, especially coating, has gradually become mature.

2. Drugscreening

The requirement to qualitativelyand quantitatively process a large number of samples in a short period of timemakes it necessary for high-throughput technology to quickly match the mostsimilar images to the required analysis images in the image analysis stage, andquerying and analyzing new data with metadata in the database is undoubtedlythe fastest. This method just fits the working steps of the electronic eye,that is, the intelligent image sensor, and their combination becomes logical.In the field of drug screening, some of the drugs need to interact with thebody or cells in vitro to analyze and screen by the performance of the cells.Therefore, the electronic eye is applied to high-throughput analysis technologyto detect cells and molecules, and it also indirectly serves the screening ofdrugs.

The progress of new technology in pharmacyin terms of application scope and development ideas will promote itsdevelopment in the direction of collaboration, integration, miniaturization,intelligence and specialization, and will definitely expand more and moreextensive application scope in the field of pharmacy.