Paroxysmal nocturnal hemoglobinuria in children
Paroxysmal nocturnal hemoglobinuria (PNH) is a chronic hemolytic disease caused by acquired hematopoietic stem cell gene mutations, which leads to erythrocyte membrane lesions. Clinically, it is characterized by intermittent intravascular hemolysis, hemoglobinuria, and hemolysis exacerbated after sleep. It can occur in both men and women, but more often in men. It is more common in young adults and is extremely rare in children. It is also called paroxysmal nocturnal hemoglobinuria, Ma-Mieszko syndrome, paroxysmal nocturnal hemoglobinuria, and paroxysmal nocturnal hemoglobinuria.
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Site of disease:
Blood vessels -
Infectious :
Not contagious -
Frequent population:
Children -
Related symptoms:
Black urine Red urine or soy sauce color Hemoglobinuria Chills Headache -
Concurrent disease:
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ethyl salicylate list
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