Helicobacter pylori is a spiral, Gram-negative, microaerophilic bacterium. Almost half of the population is infected for life, and the infection sites are mainly in the stomach and duodenal bulb. As early as 1893, Bizzozero reported observing a spiral microorganism in the stomach of dogs. Later, Kreintz and Rosenow also found spirochetes in the human stomach. In 1979, Warren found that most gastric mucosal biopsy specimens of patients with chronic gastritis and peptic ulcers were colonized with Campylobacter-like bacteria, which existed regularly on the surface of the mucosal cell layer and under the mucus layer, and were easily stained with Warthin-Starry saturated silver staining. It was not until 1983 that Marshall and Warren used the microaerobic culture method of Campylobacter to successfully isolate this bacterium for the first time. Since then, it has aroused widespread interest and in-depth research in the medical community. Later, it was found that many characteristics of this bacterium were similar to those of the Campylobacter genus, and it was named "Campylobacter pylori (CP)".