Within the therapeutic dose range, it has both (1) and non-selective (2) receptor blocking effects, and has no intrinsic sympathomimetic activity. It blocks the (1) receptors on the postsynaptic membrane, thereby dilating blood vessels and reducing peripheral vascular resistance; it blocks the (2) receptors, inhibits the secretion of renin by the kidneys, blocks the renin-angiotensin-aldosterone system, and produces a hypotensive effect. Carvedilol lowers blood pressure rapidly and can maintain its hypotensive effect for a long time. It has no effect on left ventricular ejection fraction, cardiac function, renal function, renal blood perfusion, peripheral blood flow, plasma electrolytes and blood lipid levels, does not affect heart rate or slightly slows it down, and rarely produces water and sodium retention.

Carvedilol has both (1) and non-selective (2) receptor blocking effects within the therapeutic dose range, and has no intrinsic sympathomimetic activity. This product blocks the (1) receptors on the postsynaptic membrane, thereby dilating blood vessels and reducing peripheral vascular resistance; it blocks the (2) receptors, inhibits the secretion of renin by the kidneys, blocks the renin-angiotensin-aldosterone system, and produces a hypotensive effect. Carvedilol lowers blood pressure rapidly and can maintain its hypotensive effect for a long time. It has no effect on left ventricular ejection fraction, cardiac function, renal function, renal blood perfusion, peripheral blood flow, plasma electrolytes and blood lipid levels, does not affect the heart rate or slightly slows it down, and rarely produces water and sodium retention.

This product is a second-generation sulfonylurea antidiabetic drug that can reduce fasting and postprandial blood sugar and reduce glycosylated hemoglobin (HbAlc) by 1% to 2%. The main function of this type of drug is to stimulate pancreatic b cells to secrete insulin, but the prerequisite is that pancreatic b cells still have a certain function of synthesizing and secreting insulin. Its mechanism is to specifically bind to the sulfonylurea receptors on the b cell membrane, thereby closing the K channel, causing changes in membrane potential, opening the Ca2 channel, and increasing Ca2 in the cytosol, which promotes insulin secretion. In addition, there are extra-pancreatic effects, including improving the insulin resistance of peripheral tissues (such as liver, muscle, and fat).

This product is a calcium channel blocker. It can prevent cell damage caused by pathological calcium overload in cells due to ischemia and other reasons. It has the following effects: 1. Relieve vasospasm, especially for the basilar artery and internal carotid artery; 2. Vestibular inhibition, which can increase blood flow in the cochlear arterioles and improve vestibular organ circulation; 3. Anti-epileptic effect, which can block pathological calcium overload in nerve cells to prevent paroxysmal depolarization and cell discharge, thereby avoiding epileptic seizures; 4. Protect the myocardium and significantly reduce ischemic myocardial damage; 5. Improve renal function and can be used for chronic renal failure; 6. Has anti-histamine effect.

This product is a bone metabolism regulator. It has a strong affinity for calcium phosphate in the body, can inhibit abnormal calcification and excessive bone absorption in the human body, relieve bone pain, reduce the concentration of serum alkaline phosphatase and urinary hydroxyproline; at low doses, it can directly inhibit osteoclast formation and prevent bone absorption, reduce bone turnover rate, increase bone density, etc. to achieve bone calcium regulation.