Hebei TIANCHENG Pharmaceutical Co., Ltd.

Adrenal cortex hormone drugs. It has anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressive effects. Its mechanism of action is: 1. Anti-inflammatory effect: It reduces and prevents the tissue's response to inflammation, thereby reducing the manifestations of inflammation. It can inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators. 2. Immunosuppressive effect: It includes preventing or inhibiting cell-mediated immune responses, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, reducing the ability of immunoglobulins to bind to cell surface receptors, and inhibiting the synthesis and release of interleukins, thereby reducing the transformation of T lymphocytes into lymphoblasts.

It has an antipyretic effect on rabbits with fever caused by bacterial endotoxins; it has an anti-inflammatory effect, can counteract the increased permeability of capillary walls caused by xylene or histamine, and has a significant antagonistic effect on adrenaline-induced acute pulmonary edema; it can shorten the sleep latency period of mice caused by sodium pentobarbital, prolong their sleep time, and can also enhance the subthreshold effect of sodium pentobarbital, causing mice to sleep, indicating a significant sedative effect; it can promote the function of the adrenal cortex of rats and increase the body's emergency response to pathogen infection; it has an inactivating effect on influenza virus type AⅠ, type AⅢ, pneumonia adenovirus (Adv) type III, type IV, enterosyncytial virus and respiratory syncytial virus (RSV).

1. This product has a strong antipyretic effect on rabbits with fever caused by bacterial endotoxins, can promote the disappearance of fever, and the effect is rapid and can last for more than 4 hours; 2. This product has a good anti-inflammatory effect, can counteract the increased permeability of capillary walls caused by xylene or histamine, and has a significant antagonistic effect on adrenaline-induced acute pulmonary edema; 3. This product can shorten the sleep latency of mice caused by sodium pentobarbital, prolong their sleep time, and can also enhance the effect of subthreshold sodium pentobarbital to induce sleep in mice. The experimental results indicate that this product has a significant sedative effect; 4. This product can significantly promote the adrenal cortex function of rats and increase the body's emergency response to pathogen infection; 5. Clinical etiological diagnosis experiments and tissue culture inactivation experiments show that this product has an inactivation effect on influenza virus type I, type III, pneumonia adenovirus (Adv) type III, type IV, enterosyncytial virus and respiratory syncytial virus (RSV). 2. Toxicology: Chuanhuning has low toxicity and is non-irritating. The LD50 of intravenous drip is 675 plus mn; 30 mg/kg.