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Pharmacological action not specified

Sulfadimethoxazole and trimethoprim (TMP) have synergistic antibacterial or bactericidal effects, because sulfa drugs act on dihydrofolate synthase, interfering with the first step of folic acid synthesis, while trimethoprim acts on the second step of folic acid anabolism, selectively inhibiting dihydrofolate reductase. Therefore, the combination of the two can double-block the folic acid metabolism of bacteria. The synergistic antibacterial effect of the two is enhanced compared to the use of a single drug, and the drug-resistant strains are reduced.

Sulfadimethoxazole and trimethoprim (TMP) have synergistic antibacterial or bactericidal effects, because sulfa drugs act on dihydrofolate synthase, interfering with the first step of folic acid synthesis, while trimethoprim acts on the second step of folic acid anabolism, selectively inhibiting dihydrofolate reductase. Therefore, the combination of the two can double-block the folic acid metabolism of bacteria. The synergistic antibacterial effect of the two is enhanced compared to the use of a single drug, and the drug-resistant strains are reduced.

It acts on dihydrofolate synthase, interfering with the first step of folic acid synthesis; combined with trimethoprim, it can doubly block the bacterial folic acid metabolism, enhance the synergistic antibacterial effect, and reduce drug-resistant strains.

Selectively inhibits dihydrofolate reductase and acts on the second step of folic acid anabolism; combined with sulfamethoxazole, it can double-block bacterial folic acid metabolism, enhance synergistic antibacterial effects, and reduce drug-resistant strains.

It has antipyretic and analgesic effects, can inhibit the synthesis and release of hypothalamic prostaglandins, restore the normal responsiveness of the receptor neurons in the body temperature regulation center, and thus have antipyretic and analgesic effects; it also has analgesic, anti-inflammatory and anti-rheumatic effects by inhibiting the synthesis of peripheral prostaglandins, and also has the effect of inhibiting platelet aggregation.

It has antipyretic and analgesic effects, can inhibit the synthesis and release of prostaglandins in the hypothalamus, restore the normal responsiveness of the receptor neurons in the body temperature regulation center, and thus have an antipyretic and analgesic effect.

It is a central nervous system stimulant that can excite the cerebral cortex, increase sensitivity to the outside world, constrict cerebral blood vessels, and enhance the effect of the first two drugs in relieving headaches.