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Sodium salicylate

Sodium salicylate structure

CAS No:
54-21-7
Formula:
C7H6O3.Na
Chemical Name:
Sodium salicylate
Synonyms:
Benzoic acid,2-hydroxy-,sodium salt (1:1);Sodium salicylate;Salicylic acid,monosodium salt;Benzoic acid,2-hydroxy-,monosodium salt;Aroall;Clin;Enterosalil;Magsalyl;Salicylic acid sodium salt;Sodium salicylate (NaO3C7H5);Monosodium salicylate;Sodium o-hydroxybenzoate;Entrosalyl;Salisod;Glutosalyl;Salsonin;Kerasalicyl;Kerosal;Nadisal;Neo-Salicyl;Sodium 2-hydroxybenzoate;Camporisin;o-Hydroxybenzoic acid monosodium salt;Enterosalicyl;Alysine;Idocyl;Saliject;NaSal 31821-45;18495-69-7;94413-51-1
Categories:
Cosmetic Ingredient > Cosmetic Preservative

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Description

Sodium Salicylate inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

DryPowder; Liquid

Sodium salicylate is an organic molecular entity.|Sodium Salicylate is the sodium salt of salicylic acid. As a nonsteroidal anti-inflammatory drug (NSAID), sodium salicylate irreversibly acetylates cyclooxygenases I and II, thereby inhibiting prostaglandin synthesis and associated inflammation and pain. This agent may also activate mitogen-activated protein kinase (p38MAPK), thereby inducing apoptosis in cancer cells. (NCI04)|A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)

Sodium salicylate Basic Attributes

Molecular Weight：

160.10300

Exact Mass：

160.01400

EC Number：

290-777-4

UNII：

WIQ1H85SYP

DSSTox ID：

DTXSID5021708

NCI Thesaurus Code：

C834

ATC Code：

N - Nervous system

HScode：

2918211000

Characteristics

PSA：

60.36000

XLogP3：

-1.43 (LogP)

Appearance：

DryPowder; Liquid

Density：

0.32 g/cm3 (20℃)

Melting Point：

213 °C (decomp)

Boiling Point：

336.3ºC at 760mmHg

Flash Point：

144.5ºC

Refractive Index：

1.435

Water Solubility：

H2O: 1000 g/L (20 ºC)

Storage Conditions：

Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

Toxicity：

LD50 i.p. in rats: 780 mg/kg (Goldenthal)

Collision Cross Section：

122.9 Å² [M-H]-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22

safety instructions：

S26; S36

RTECS Number：

VO5075000

Marks：

Stability/Shelf Life：

Stable. Incompatible with mineral acids, metallic salts, iodine. May be light-sensitive.

Precautionary statement(s)：

P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302-H319

GHS Classification：

|Warning|H302 (96.98%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P305+P351+P338, P308+P313, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 434 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

MeSH Entry Terms：

Salicylate, Sodium

Sodium salicylate Use and Manufacturing

Uses

An analgesic and antipyretic.Organic synthetic raw materials, preservatives, reagents for measuring free acids in gastric juice. Antipyretic analgesics and antirheumatic drugs. Antipyretic and analgesic, anti-rheumatic drugs, used for the treatment of active rheumatism, rheumatoid arthritis and other diseases. It is used for microanalysis and determination of uranium dioxide and organic synthesis, and as a preservative. Used for spot analysis of uranium dioxide; used for measuring free acid in gastric juice. Used as raw materials for organic synthesis; preservatives; reagents for measuring free acids in gastric juice; spot analysis of uranium dioxide.

Lubricants and lubricant additives

Animal Feed

Production

500,000 - 1,000,000 lb

Manufacturing Info：

Agriculture, forestry, fishing and hunting|Benzoic acid, 2-hydroxy-, sodium salt (1:1): ACTIVE

Use Classification：

Cosmetics -> Preservative

Computed Properties

Molecular Weight:160.10
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:160.01363830
Monoisotopic Mass:160.01363830
Topological Polar Surface Area:60.4
Heavy Atom Count:11
Complexity:138
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Carbon dioxide

Sodium benzoate

Salicylic acid

Downstream Products

Terephthalic acid

Phenol

Sodium formate

Aspirin

Benzoic acid

Drug Function and Efficacy

By inhibiting cyclooxygenase and reducing the synthesis of prostaglandins, it has anti-inflammatory, anti-rheumatic, antipyretic and analgesic effects. Its anti-inflammatory and anti-rheumatic effects are similar to those of aspirin, but its antipyretic and analgesic effects are weaker. This product has no antiplatelet aggregation effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Sodium Salicylate Tablets
Ingredients	Sodium salicylate
Indication	1 When this product is used in combination with other salicylic acid drugs, their toxicity can be enhanced. 2 When this product is used in combination with dicoumarol, it displaces the latter from the plasma protein binding site, increases the blood concentration of free dicoumarol, enhances its anticoagulant effect, and is prone to bleeding. 3 This product can also displace the sulfonylurea hypoglycemic drug tolbutamide, enhance its hypoglycemic effect, and is prone to hypoglycemia. 4 When used in combination with adrenal cortical hormones, the anti-inflammatory effect of hormones is also enhanced due to protein replacement, but the ulcer-inducing effect is also enhanced. 5 This product reduces the secretion of methotrexate from the renal tubules and enhances its toxicity. 6 When used in combination with furosemide, it competes with the renal tubular secretion system.
Specifications	0.3g
Manufacturer	Hainan Pharmaceutical FACTORY Co., Ltd.

Sodium Salicylate Tablets
Ingredients	Sodium salicylate
Indication	1 When this product is used in combination with other salicylic acid drugs, their toxicity can be enhanced. 2 When this product is used in combination with dicoumarol, it displaces the latter from the plasma protein binding site, increases the blood concentration of free dicoumarol, enhances its anticoagulant effect, and is prone to bleeding. 3 This product can also displace the sulfonylurea hypoglycemic drug tolbutamide, enhance its hypoglycemic effect, and is prone to hypoglycemia. 4 When used in combination with adrenal cortical hormones, the anti-inflammatory effect of hormones is also enhanced due to protein replacement, but the ulcer-inducing effect is also enhanced. 5 This product reduces the secretion of methotrexate from the renal tubules and enhances its toxicity. 6 When used in combination with furosemide, it competes with the renal tubular secretion system.
Specifications	0.3g
Manufacturer	GRAND PHARMACEUTICAL(China) Co., Ltd.

Sodium salicylate
Specifications	API
Manufacturer	Guangdong Jiuming Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

JQC HUAYIN PHARMACEUTICAL CO LTD

United States
Active
Pharmaceutical Works Polpharma S.A.

Japan
Active
UBE株式会社

Japan
Active

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