Livzon (GROUP) Pharmaceutical FACTORY

It exerts its antibacterial activity by inhibiting the synthesis of bacterial cell walls, and has antibacterial activity against aerobic Gram-positive bacteria (such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes) and aerobic Gram-negative bacteria (such as Escherichia coli, Klebsiella pneumoniae, Proteus).

This product belongs to the aminoglycoside antibiotics, and its antibacterial spectrum is similar to that of gentamicin. It has antibacterial effects on a variety of Gram-negative bacteria, and its antibacterial effect on Pseudomonas aeruginosa is 3 to 5 times stronger than that of gentamicin. Some Gram-positive bacteria such as Staphylococcus aureus are sensitive to it, but streptococci and anaerobic bacteria are resistant to it. The mechanism of action is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins.

It has high activity against protozoa and anaerobic bacteria, and can inhibit most anaerobic bacteria; microaerophilic bacteria and Helicobacter pylori are sensitive to it; the activity of its metabolites against Gardnerella is stronger than that of tinidazole. The mechanism of action is to reduce the DNA metabolism of bacteria into cytotoxicity, promote bacterial death, and inhibit the redox reaction of amoeba, causing the nitrogen chain to break and kill the protozoa.

This product is a semi-synthetic 14-membered macrolide antibiotic. Its antibacterial spectrum and antibacterial effect are basically similar to those of erythromycin. Its effect on Gram-positive bacteria is slightly worse than that of erythromycin, and its effect on Legionella pneumophila is stronger than that of erythromycin. Its antimicrobial effect on Chlamydia pneumoniae, Mycoplasma pneumoniae, and Ureaplasma urealyticum is similar to or slightly stronger than that of erythromycin. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor (P position), blocking the transfer RNA (t-RNA) from binding to the P position, and also blocking the transfer of the polypeptide chain from the acceptor position (A position) to the P position, thereby inhibiting bacterial protein synthesis.

This product is a broad-spectrum protease inhibitor and has inhibitory effects on plasmin and other enzymes.