Topfond Pharmaceutical Co., Ltd.

This product belongs to Class III antiarrhythmic drugs. The main electrophysiological effect is to prolong the action potential and effective refractory period of various myocardial tissues, which is conducive to eliminating reentrant excitement. At the same time, it has mild non-competitive α and β adrenergic receptor blocking and mild Class I and IV antiarrhythmic properties. Reduce the automaticity of the sinus node. It has no effect on the resting membrane potential and action potential height. The inhibition of forward conduction of the atrioventricular bypass pathway is greater than the reverse. Due to excessive prolongation of repolarization, the electrocardiogram after oral administration has a prolonged QT interval and T wave changes, which can slow down the heart rate by 15~20% and prolong the PR and Q-T intervals by about 10%. It has a direct dilation effect on the coronary arteries and peripheral blood vessels. It can affect thyroid hormone metabolism.

Tetracycline antibiotics. This product is a broad-spectrum antibacterial agent. Many Rickettsia, Mycoplasma, Chlamydia, and Spirochete are sensitive to this product. Enterococci are resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, etc. are also sensitive to this product. Due to the widespread use of oxytetracycline and tetracyclines over the years, common clinical pathogens have serious resistance to oxytetracycline, including Gram-positive bacteria such as Staphylococcus and most Gram-negative bacteria. There is cross-resistance between this product and different varieties of tetracycline antibiotics. The mechanism of action of this product is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, inhibit the growth of the peptide chain and affect the synthesis of bacterial proteins.

By competitively inhibiting the adsorption of plasminogen on the fibrin network, the activation of plasminogen is reduced, thereby inhibiting the degradation of fibrin and bleeding.

It promotes brain metabolism and improves brain circulation by reducing cerebrovascular resistance and increasing cerebral blood flow. It also enhances the function of the ascending activation system of the brainstem reticular structure, the function of the pyramidal system, improves motor paralysis, and has a certain effect on promoting the recovery of brain function and awakening.

This product can directly penetrate the cell membrane into the body cells, activate pyruvate oxidase, so that cells in a low-energy and hypoxic state can continue to metabolize smoothly, and participate in the energy metabolism and protein synthesis of the human body.