Netilmicin is a semi-synthetic aminoglycoside broad-spectrum antibiotic that works by inhibiting the normal protein synthesis of sensitive microorganisms. It has a wide range of antimicrobial effects, mainly targeting Gram-negative bacteria and a few Gram-positive bacteria.

Netilmicin is a semi-synthetic aminoglycoside broad-spectrum antibiotic, and its mechanism of action is to inhibit the normal protein synthesis of sensitive microorganisms. This product has a wide range of antimicrobial effects, mainly targeting Gram-negative rods and a few Gram-positive bacteria, including Citrobacter, Enterobacter, Escherichia coli, Klebsiella, Morgan Proteus, Pseudomonas aeruginosa, Salmonella, Shigella and Staphylococcus (penicillin- and methicillin-resistant). This product is also active in vitro against some isolated Acinetobacter, Neisseria, indole-positive Proteus, Pseudomonas, and Serratia. Most streptococci and anaerobic microorganisms such as Clostridium are resistant to aminoglycosides.

This product is a broad-spectrum antibiotic, which has antibacterial activity against some Gram-positive and Gram-negative bacteria, especially against Streptococcus (except Enterococcus) and Pneumococcus among Gram-positive bacteria, and gonococci, Branhamella, Escherichia coli, Klebsiella, Serratia, Proteus, and influenza bacilli among Gram-negative bacteria. Its mechanism of action is bactericidal, and it works by preventing the synthesis of bacterial cell walls. It has a high affinity with 1 (la, lb, 1c) and 3 in penicillin-binding protein (PBP). This product has extremely strong stability against β-lactamases produced by various bacteria, and shows excellent antibacterial power against bacteria that produce β-lactamases.

1. Anti-tumor effect: (1) It shows high anti-tumor activity against mouse leukemia L-1210. (2) It has a wide anti-tumor spectrum against mouse transplanted tumors, including lymphocytic leukemia L1210, granulocytic leukemia C-1498, plasmacytoma X-5563 (ascites type), Ehrlich's ascites carcinoma and dural sarcoma MS-147. (3) It has a life-extending effect on mice with intracerebral transplantation of lymphocytic leukemia L1210 and methylcholanthrene-induced malignant glioma cells. 2. Mechanism of action: It mainly inhibits DNA synthesis by alkylating intracellular DNA, resulting in low molecular weight DNA.

This product has a broad-spectrum antibacterial effect and strong antibacterial effect. It has strong antibacterial activity against most Enterobacteriaceae, and also has antibacterial effect against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae, Mycoplasma pneumoniae, and Chlamydia pneumoniae. Its mechanism of action is to inhibit the activity of bacterial DNA gyrase, prevent the synthesis and replication of bacterial DNA, and cause bacterial death.