Nimustine Hydrochloride for Injection

1 Anti-tumor effect: (1) It shows high anti-tumor activity against mouse leukemia L-1210. (2) It has a wide anti-tumor spectrum against mouse transplanted tumors. It shows excellent effects on lymphocytic leukemia L1210, granulocytic leukemia C-1498, plasmacytoma X-5563 (ascites type), Ehrlich's ascites carcinoma, and dural sarcoma MS-147. (3) This agent has a life-extending effect on mice with lymphocytic leukemia L1210 and methylcholanthrene-induced malignant glioma cells transplanted into the brain. 2 Mechanism of action: The main mechanism of action is to alkylate the DNA in the cell and reduce the molecular weight of the DNA, thereby inhibiting DNA synthesis.

Nimustine hydrochloride.

This product is light yellow loose mass or powder.

Relieve the subjective symptoms and signs of the following diseases: brain and neck cancer, brain tumors, lung cancer, digestive tract cancer (gastric cancer, colon/rectum cancer, esophageal cancer), malignant lymphoma and leukemia, etc.

Common dosage: 2-3 mg/kg body weight/time, dissolved in water for injection (5 mg/ml), intravenous injection. Then stop the drug for 4-6 weeks according to the peripheral blood picture, or 2 mg/kg body weight/time, intravenous administration, give it once every week, and then stop the drug for 4-6 weeks according to the peripheral blood picture after 2-3 weeks. This product should be used immediately after being prepared into solution.

Symptoms such as leukopenia, thrombocytopenia, anemia, bleeding tendency, allergies, loss of appetite, nausea, fatigue, fever, headache, hair loss and hypoproteinemia may be seen, and occasionally the liver and kidney functions may be slightly affected and interstitial pneumonia may occur.

The following patients should use the drug with caution: 1. Patients with impaired liver function. 2. Patients with impaired kidney function. 3. Patients with concurrent infection. 4. Patients with water beans (sometimes with fatal systemic disorders). Side effects: See relevant medical information for details.

Precautions for children: Children are prone to adverse reactions (leukopenia, etc.) because their metabolic systems are not yet mature, so they should be carefully observed and administered with caution. Precautions for pregnancy and lactation: 1. It is reported that animal experiments have teratogenic effects, so pregnant women or women who may become pregnant are prohibited from using this drug. 2. The safety of the drug during lactation has not yet been established, so lactating women should stop breastfeeding when taking the drug.

When used in combination with other anti-tumor drugs or radioactive rays, bone marrow suppression may sometimes be aggravated.

Store in a cool, dark place away from light.

25mg

24 months

Shanxi Zhendong Taisheng Pharmaceutical Co., Ltd.

• Founded in:

  1993-07-05

• Address:

  The First Pharmaceutical Park, Economic and Technological Development Zone, Datong City, Shanxi Province

• Tax NO.:

  91140200602165291J

• Registered Funds:

  395 million yuan

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