It has a selective excitatory effect on the spinal cord, enhancing reflexes and muscle tension

1. Calcium ion antagonist, regulates calcium ion influx on the membrane of myocardial conduction cells, myocardial contractile cells and arterial smooth muscle cells, without changing serum calcium concentration; 2. Dilates the main coronary artery and arterioles, antagonizes coronary artery spasm, increases myocardial oxygen delivery, and reduces myocardial oxygen consumption; 3. Prolongs the effective refractory period of the atrioventricular node, slows conduction, and reduces the ventricular rate of patients with chronic atrial fibrillation and atrial flutter; 4. Reduces vascular resistance in the systemic circulation to produce a hypotensive effect; 5. Reduces afterload, inhibits myocardial contraction, and improves left ventricular diastolic function; 6. Has local anesthetic effect (animal test); 7. Non-carcinogenic and non-mutagenic.

This product has analgesic, anti-inflammatory and antipyretic effects. Its mechanism of action is to reduce the synthesis of prostaglandins by inhibiting cyclooxygenase, thereby alleviating tissue congestion and swelling caused by prostaglandins and reducing the sensitivity of peripheral nerve pain. It has an antipyretic effect through the hypothalamic temperature regulation center.

Amikacin sulfate is an aminoglycoside antibiotic that has good antibacterial effects on most Enterobacteriaceae, Pseudomonas aeruginosa and other Pseudomonas, Acinetobacter, Alcaligenes, etc. It also has good antibacterial effects on meningococci, gonococci, influenza bacilli, Yersinia, Campylobacter fetus, Mycobacterium tuberculosis and some Mycobacterium. Its antibacterial activity is slightly lower than that of gentamicin, but it is stable to the aminoglycoside inactivating enzymes produced by many intestinal Gram-negative bacilli. The mechanism of action is to act on the 30S subunit of the bacterial ribosome and inhibit bacterial protein synthesis. Combination with semi-synthetic penicillins or cephalosporins often achieves a synergistic antibacterial effect.

It has a strong antibacterial effect on most anaerobic bacteria, and has a strong killing effect on amoeba and trichomonas. Its bactericidal mechanism has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro group of this product is reduced to a cytotoxin, which acts on the DNA metabolism process of bacteria and promotes cell death.

Can reduce the adverse reactions of metronidazole.