JiangSu Ruinian Qianjin Pharmaceutical Co., Ltd.

Nateglinide is an amino acid derivative and an oral antidiabetic drug used to treat patients with type 2 diabetes. The action of nateglinide depends on the function of pancreatic beta cells. Nateglinide binds to the ATP-sensitive K channel receptor on the beta cell membrane and closes it, causing cell depolarization, calcium channel opening, calcium influx, stimulating insulin secretion, and lowering blood sugar. The insulin secretion-promoting effect of nateglinide depends on the glucose level. When the glucose level is low, the insulin secretion is weakened. Nateglinide has a high degree of tissue selectivity and has a low affinity for cardiac muscle and skeletal muscle.

This product belongs to the quinolone antibacterial drug. Its main mechanism of action is to inhibit the activity of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus, hinder DNA synthesis and cause bacterial death; it has a weak inhibitory effect on human topoisomerase II. This product has the characteristics of a broad antibacterial spectrum and strong antibacterial effect. It has good antibacterial activity against G bacteria such as Staphylococcus, Streptococcus, Enterococcus, and G- bacteria such as Escherichia coli, Proteus mirabilis, Klebsiella, Enterobacter cloacae, Citrobacter, Acinetobacter calcoaceticus, Haemophilus influenzae, Moraxella catarrhalis, Pseudomonas aeruginosa, etc. This product also has good antibacterial activity against some anaerobic bacteria such as Clostridium perfringens, Fusobacterium nucleatum, Propionibacterium acnes, Porphyromonas, some Peptostreptococci, Bacteroides fragilis and Prevotella.

It combines with poisons containing hydroxyl or carboxyl groups to form low-toxic or non-toxic compounds that are excreted in the urine, protecting the liver and detoxifying. Glucuronic acid can increase the glycogen content of the liver and reduce fat reserves.

This product belongs to the macrolide antibiotics, which is the dodecyl sulfate of erythromycin propionate. It has antibacterial activity against Staphylococcus, various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. may also be sensitive to this product. This product also has antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; it also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can pass through the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis. This product is only effective against bacteria with active division.

This product acts directly on the bronchial glands, releasing the lysosomes of mucus-secreting cells, thereby depolymerizing the mucopolysaccharides in the mucus and reducing the viscosity of the mucus; it can also cause the respiratory tract to secrete low-viscosity small-molecule mucins, making the sputum thinner and easier to cough up.