Jiangsu Lianhuan Pharmaceutical Co., Ltd.

Improve the sensitivity of liver and peripheral tissues to insulin, improve glucose uptake and utilization. It may also have the effect of improving blood lipid levels and fibrinolytic protein activity.

It can stimulate pancreatic β cells to secrete insulin. Its mechanism of action is to specifically bind to the sulfonylurea receptors on the β cell membrane, thereby closing the potassium ion channel and causing a change in membrane potential. As a result, the calcium ion channel opens, and the calcium ions in the cytosol increase, prompting the secretion of insulin. It also has an extrapancreatic effect, which can reduce the liver's insulin resistance to peripheral tissues (muscle, fat). In addition, gliclazide can also reduce platelet adhesion and aggregation, and has fibrinolytic activity.

This product is an antifibrinolytic drug. It competitively inhibits plasminogen with the fibrin binding site, preventing it from activating into plasmin, thereby inhibiting fibrinolysis; at high concentrations, it directly inhibits the activity of plasmin and achieves a hemostatic effect.

Methylcobalamin is an endogenous coenzyme B12. It plays an important role as a coenzyme of methionine synthase in the transmethylation reaction of methionine synthesized from homocysteine. It is easily transferred to the organelles of nerve cells, thereby promoting the synthesis of nucleic acids and proteins. It is easier to transfer into the organelles of nerve cells than cyanocobalamin, and participates in the process of synthesizing thymidine from deoxyuridine in brain cells and spinal cord nerve cells, promoting the utilization of folic acid and the metabolism of nucleic acids. It can promote the synthesis of nucleic acids and proteins better than cobalamin, and promotes intra-axonal transport and axonal regeneration.

After passing through the blood-brain-spinal fluid barrier, it is decomposed into glutamate and g-aminobutyric acid (GABA); glutamate is involved in information transmission in the central nervous system; g-aminobutyric acid can antagonize the excitotoxic effects of glutamate, improve nerve cell metabolism, maintain nerve stress resistance, reduce the effects of blood ammonia, and improve brain function.

No specific pharmacological effects mentioned