Jiangsu Jibeier Pharmaceutical Co., Ltd.

It has high antibacterial activity against common aerobic Gram-positive bacteria, such as Staphylococcus aureus (including those resistant to penicillin G), Staphylococcus epidermidis, beta-hemolytic Streptococcus, viridans Streptococcus and Streptococcus pneumoniae. It has good antibacterial effect on anaerobic bacteria, including Clostridium diphtheriae, and Clostridium perfringens. It has no activity against Gram-negative bacteria such as enterococci, meningococci, Neisseria gonorrhoeae, and Haemophilus influenzae, as well as fungi. There is no cross-resistance with penicillin, chloramphenicol, cephalosporins and tetracyclines, and there is partial cross-resistance with macrolides. It acts on the 50S subunit of the ribosome of sensitive bacteria, preventing the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. It is generally an antibacterial agent, but at high concentrations, it also has a bactericidal effect on certain bacteria.

This product belongs to the macrolide antibiotics, which is the dodecyl sulfate of erythromycin propionate. It has antibacterial activity against Staphylococcus, various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. may also be sensitive to this product. This product also has antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; it also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can pass through the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis. This product is only effective against bacteria with active division.

The antibacterial property is similar to that of erythromycin. It has a strong antibacterial effect on Gram-positive bacteria, and is effective against Staphylococcus, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Diphtheria bacillus, Tetanus bacillus, and anthrax bacillus. It also has antibacterial effects on Gram-negative bacteria such as gonococci and pertussis bacillus. It is also effective against Leptospira, Rickettsia, and Mycoplasma. It can be used as a substitute for erythromycin for infections of the oropharynx, respiratory tract, skin and soft tissue, and bile duct caused by the above-mentioned sensitive bacteria.

The antibacterial property is similar to that of erythromycin. It has a strong antibacterial effect on Gram-positive bacteria, and is effective against Staphylococcus, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Diphtheria bacillus, Tetanus bacillus, and anthrax bacillus. It also has antibacterial effects on Gram-negative bacteria such as gonococci and pertussis bacillus. It is also effective against Leptospira, Rickettsia, and Mycoplasma. It can be used as a substitute for erythromycin for infections of the oropharynx, respiratory tract, skin and soft tissue, and bile duct caused by the above-mentioned sensitive bacteria.

It has the effects of relieving asthma, relieving cough, removing phlegm, sedation, antispasmodic, and anticonvulsant. Relieving asthma: It can counteract histamine and acetylcholine and relieve bronchospasm; relieving cough: It has a strong inhibitory effect on the cough center; removing phlegm: It causes increased secretion, thins thick sputum, reduces sputum viscosity, and makes it easier to cough up; sedation: It has a sedative effect close to diazepam, significantly reduces spontaneous activity without an inhibitory effect; antispasmodic: It is similar to aminophylline and has the effect of relaxing bronchial smooth muscles. Anticonvulsant: It can increase the electrical stimulation threshold of the cerebral cortex, inhibit the synaptic conduction of electrical stimulation and the spread of epileptic electricity, thereby preventing or alleviating epileptic seizures.