Levofloxacin is the L-isomer of ofloxacin (racemate) and is a quinolone antibacterial drug. Its antibacterial mechanism is to inhibit topoisomerase IV and DNA gyrase (topoisomerase II) required for bacterial DNA replication, transcription, repair and recombination. It has antibacterial effects on a variety of Gram-negative and Gram-positive bacteria, and has bactericidal activity when the concentration is equal to or slightly higher than the inhibitory concentration.

After entering the body, it is hydrolyzed into clindamycin by alkaline phosphatase in the blood, which has antibacterial effect. After intravenous drip of 600 mg, the blood concentration reaches a peak immediately, and the effective blood concentration can be maintained for more than 8 hours. It is mainly metabolized in the liver and excreted through bile and feces.

After clindamycin phosphate enters the body, it is quickly hydrolyzed into clindamycin by alkaline phosphatase in the blood. The pharmacokinetics of normal people show that effective blood concentration can be reached and maintained for more than 8 hours after a single intravenous drip or intramuscular injection. It is mainly metabolized in the liver and excreted through bile and feces, and partially excreted through urine.

After entering the body, it is hydrolyzed into clindamycin by alkaline phosphatase in the blood. After a single intravenous drip of 600 mg, the clindamycin in the blood immediately reaches a peak concentration of (11.09±2.02) mg/L, and the blood concentration is (1.69±0.35) mg/L in 8 hours; after a single intramuscular injection of 600 mg, the clindamycin in the blood reaches a peak concentration of (5.92±1.45) mg/L in 1 to 2 hours, and the blood concentration is (2.51±0.91) mg/L in 8 hours. The effective blood concentration can be maintained for more than 8 hours. It is mainly metabolized in the liver and excreted in bile and feces, and partially excreted in urine.

After entering the body, it is quickly hydrolyzed into clindamycin under the action of alkaline phosphatase in the blood. The pharmacokinetics of normal people show that it has obvious changes in blood drug concentration and metabolic characteristics. It is mainly metabolized in the liver and excreted through bile and feces, and partially excreted through urine.