Jiangsu Langou Pharmaceutical Co., Ltd.

It has anti-cerebral ischemia effect, improves brain edema in rats with multiple cerebral infarction, promotes glial cell reaction of brain softening foci, accelerates the absorption and organization of softening foci, and reduces neuronal lesions in the hippocampus; it has a protective effect on delayed neuronal damage in the hippocampus of gerbils with transient cerebral ischemia, can reduce the Ca2+ content in brain tissue after ischemia, reduce the number of dead neurons, and increase neuronal density. It has anti-myocardial ischemia effect, can reduce the downward shift of the S-T segment of the electrocardiogram caused by acute myocardial ischemia in rats, and adjust the heterogeneity of the electrocardiogram. It improves blood rheology, reduces whole blood viscosity and plasma viscosity, reduces hematocrit and platelet aggregation rate, slows down erythrocyte sedimentation rate, and reduces fibrinogen content. It improves microcirculation, reduces the morphological integral, flow integral, semi-circular integral, and overall integral of the nail fold microcirculation, reduces peri-loop exudation, increases flow velocity, reduces red blood cell aggregation, reduces congestion, increases loop clarity, and subsides edema. It has the effect of lowering blood lipids, reducing total cholesterol and triglycerides, and reducing serum triglycerides, cholesterol and low-density lipoprotein levels. It has the effect of resisting free radical damage, increasing the activity of superoxide dismutase in erythrocytes, reducing plasma malondialdehyde content, and reducing serum protein kinase C and aspartate aminotransferase content.

It has anti-cerebral ischemia effect, can improve brain edema in rats with multiple cerebral infarctions, promote the glial cell reaction of brain softening foci, accelerate the absorption and organization of softening foci, and reduce neuronal lesions in the hippocampus; it has a protective effect on delayed neuronal damage in the hippocampus of gerbils with transient cerebral ischemia, can reduce the Ca2+ content in brain tissue after ischemia, reduce the number of dead neurons, and increase neuronal density. It has anti-myocardial ischemia effect, can reduce the downward shift of the S-T segment of the electrocardiogram in rats with acute myocardial ischemia, and adjust the heterogeneity of the electrocardiogram. It improves blood rheology, can reduce whole blood viscosity, plasma viscosity, hematocrit and platelet aggregation rate, slow down the erythrocyte sedimentation rate, and reduce fibrinogen content. It improves microcirculation, can reduce the morphological integral, flow integral, semi-circular integral and overall integral of the nail fold microcirculation, reduce peri-loop exudation, reduce the tube diameter, increase the flow rate, reduce the aggregation of red blood cells, reduce the congestion of the top of the loop, increase the clarity of the tube loop, and eliminate edema. It has the effect of lowering blood lipids, reducing total cholesterol, triglycerides, and low-density lipoprotein levels. It has the effect of resisting free radical damage, increasing the activity of superoxide dismutase in erythrocytes, reducing the content of malondialdehyde in plasma, and reducing the content of serum protein kinase C and aspartate aminotransferase.

This product has a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli. It has good antibacterial activity in vitro against the following bacteria: most bacteria of the Enterobacteriaceae family, including Citrobacter, Enterobacter cloacae, Enterobacter aerogenes, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. It often has antibacterial activity against multi-drug resistant bacteria. It has high antibacterial activity against penicillin-resistant Neisseria gonorrhoeae, enzyme-producing Haemophilus influenzae and Moraxella. It has antibacterial activity against most strains of Pseudomonas such as Pseudomonas aeruginosa. This product has antibacterial activity against methicillin-sensitive Staphylococcus aureus, and only moderate antibacterial activity against Streptococcus pneumoniae, hemolytic Streptococcus and Enterococcus faecalis. It has good antimicrobial activity against Chlamydia trachomatis, Mycoplasma, Legionella, and also has antibacterial activity against Mycobacterium tuberculosis and atypical mycobacteria. Poor antibacterial activity against anaerobic bacteria. Ofloxacin is a bactericide that acts on the A subunit of bacterial DNA helicase, inhibiting DNA synthesis and replication, leading to bacterial death.

This product is an amide local anesthetic. After blood absorption or intravenous administration, it has obvious biphasic effects of excitation and inhibition on the central nervous system, and there may be no precursor excitation. When the blood concentration is low, analgesia and drowsiness occur, and the pain threshold increases; with increasing doses, the effect or toxicity increases, and it has an anticonvulsant effect at sub-toxic blood concentrations; convulsions may occur when the blood concentration exceeds 5μg·ml-1. At low doses, this product can promote the outflow of K in myocardial cells, reduce myocardial autonomy, and have an anti-ventricular arrhythmia effect; at therapeutic doses, it has no obvious effect on the electrical activity of myocardial cells, atrioventricular conduction, and myocardial contraction; further increases in blood concentrations can cause a slowing of heart conduction velocity, atrioventricular conduction block, inhibition of myocardial contractility, and a decrease in cardiac output.

It selectively excites the respiratory center in the medulla oblongata, and can also act on the carotid body and aortic body chemoreceptors to reflexively excite the respiratory center, and increase the sensitivity of the respiratory center to carbon dioxide, making breathing deeper and faster. It has a weak excitatory effect on the vasomotor center. Excessive doses can cause convulsions.