HUAZHONG Pharmaceutical Co., Ltd.

This product is a non-steroidal anti-inflammatory drug. Its analgesic, anti-inflammatory and antipyretic effects work by inhibiting the synthesis of prostaglandins.

It has high antibacterial activity against common aerobic Gram-positive bacteria, such as Staphylococcus aureus (including those resistant to penicillin G), Staphylococcus epidermidis, beta-hemolytic Streptococcus, viridans Streptococcus and Streptococcus pneumoniae. It has good antibacterial effect on anaerobic bacteria, including Clostridium diphtheriae, and Clostridium perfringens. It has no activity against Gram-negative bacteria such as enterococci, meningococci, Neisseria gonorrhoeae, and Haemophilus influenzae, as well as fungi. There is no cross-resistance with penicillin, chloramphenicol, cephalosporins and tetracyclines, and there is partial cross-resistance with macrolides. It acts on the 50S subunit of the ribosome of sensitive bacteria, preventing the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. It is generally an antibacterial agent, but at high concentrations, it also has a bactericidal effect on certain bacteria.

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This product is a synthetic antibacterial anti-tuberculosis drug. It has strong activity against bacteria in the growth and reproduction stage, and has almost no effect on bacteria in the dormant stage. It has high antibacterial activity against various types of mycobacteria. There is no cross-resistance between Mycobacterium tuberculosis and this product and other drugs. It may inhibit the metabolism of sensitive bacteria, inhibit RNA synthesis, and interfere with the protein metabolism of Mycobacterium tuberculosis, thereby causing bacterial death. In large doses, it can cause cleft palate, brain exposure, and spinal deformity in mouse experiments; it can cause mild cervical deformity in rat experiments; it can cause cyclops, short limbs, and cleft palate in rabbit experiments.

This product is a benzimidazole derivative, which is rapidly metabolized into sulfoxide, sulfone alcohol and 2-amine sulfone alcohol in the body. It selectively and irreversibly inhibits the polymerization of the cytoplasmic microtubule system of the parasite's intestinal wall cells, blocks its absorption of various nutrients and glucose, leads to the depletion of endogenous glycogen in the worm, and inhibits the fumarate reductase system, preventing the production of adenosine triphosphate, making it impossible for the worm to survive and reproduce. It can also cause the degeneration of the cytoplasmic microtubules of the worm's intestinal cells, and bind to its microtubule protein, causing intracellular transport blockage, resulting in the accumulation of Golgi endocrine granules, the gradual dissolution of the cytoplasm, and the complete degeneration of the absorbing cells, causing the death of the worm. It has the effect of completely killing hookworm eggs and whipworm eggs and partially killing ascarid eggs. In addition to killing and expelling various nematodes parasitic in animals, it also has a significant killing and expelling effect on tapeworms and cysticerci. Toxicological tests show that this product is low in toxicity and safe.