CSPC OUYI Pharmaceutical Co., Ltd.

The first generation of cephalosporins has a broad antibacterial spectrum and strong activity against Gram-positive bacteria. It is sensitive to penicillinase-producing and non-penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococcus, Streptococcus pyogenes, Streptococcus pneumoniae, group B hemolytic Streptococcus, viridans Streptococcus, Staphylococcus epidermidis, Corynebacterium diphtheriae, and Bacillus anthracis; highly sensitive to Haemophilus influenzae, Neisseria meningitidis, Moraxella catarrhalis, and Neisseria gonorrhoeae; moderately sensitive to some strains of Escherichia coli, Klebsiella, Salmonella, Shigella, and Proteus; sensitive to Gram-positive anaerobic bacteria, and resistant to Bacteroides fragilis. It mainly inhibits the synthesis of bacterial cell walls.

This product is an antibacterial drug. Escherichia coli is mostly sensitive to this product, and some strains of Enterobacteriaceae such as Enterobacter aerogenes, Enterobacter cloacae, Proteus, and Klebsiella are sensitive to this product. Aeruginosa is usually resistant to this product. This product has antibacterial effects on Gram-positive bacteria such as Enterococcus. The antibacterial activity of this product is not affected by pus and tissue decomposition products. It is more active in acidic urine. The antibacterial mechanism is to interfere with the oxidoreductase system in the bacteria, thereby blocking its metabolic process.

It has high antibacterial activity against most aerobic Gram-negative bacteria, inhibiting the synthesis of bacterial cell walls by highly binding to penicillin-binding protein (PBP3) on the cell membrane of sensitive aerobic Gram-negative bacteria. It does not induce bacteria to produce b-lactamase, and is highly stable to most b-lactamases produced by bacteria.

It has high antibacterial activity against most aerobic Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae and Oxytobacter, aerogenes, Cloacae, Proteus, Serratia, Citrobacter, Shigella and other Enterobacteriaceae, as well as influenza bacilli, gonococci, meningococci, etc. It also has good antibacterial effect against Pseudomonas aeruginosa, but has poor antibacterial effect against some Pseudomonas and Acinetobacter species other than Pseudomonas aeruginosa, and has no antibacterial activity against aerobic Gram-positive bacteria such as Staphylococcus and Streptococcus, as well as anaerobic bacteria. It inhibits the synthesis of bacterial cell walls by highly binding to penicillin-binding protein (PBP3) on the cell membrane of sensitive aerobic Gram-negative bacteria. Unlike most b-lactam antibiotics, it does not induce bacteria to produce b-lactamases, and is highly stable to most b-lactamases produced by bacteria.