Shandong Zibo Xinda Pharmaceutical Co., Ltd.

This product is a broad-spectrum semi-synthetic penicillin with extremely low toxicity. The antibacterial spectrum is similar to that of penicillin, and it has a strong antibacterial effect on grass-green streptococci, hemolytic streptococci, and enterococci. Diphtheria bacillus, anthrax bacillus, Gram-positive anaerobic cocci and bacilli are sensitive to this product; meningococci, pertussis bacilli, and Brucella are also very sensitive. Escherichia coli, Salmonella, Shigella dysenteriae, Proteus, influenza bacilli, pneumococci, gonococci, etc., all have varying degrees of drug resistance because some strains produce beta-lactamase. Among them, the resistance rate of Escherichia coli is as high as 50-60%. Enterobacter bacteria, Pseudomonas aeruginosa, and anaerobic Gram-negative bacilli are resistant to this product. It is mainly used to treat infectious diseases caused by sensitive Staphylococcus aureus, hemolytic streptococci, gonococci, meningococci, diphtheria, pertussis, influenza bacilli, Salmonella, Shigella, etc.; such as respiratory tract infections (pneumonia, acute and chronic bronchitis, whooping cough, etc.), gastroenteritis and digestive tract infections (liver and gallbladder infections, acute and chronic gastroenteritis, bacillary dysentery, typhoid and paratyphoid, etc.), urinary tract infections (gonorrhea, urethritis, cystitis, etc.), soft tissue infections and sepsis, meningitis, endocarditis, etc.

This product is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. Its mechanism of action may be mainly related to the inhibition of prostaglandin synthesis, mediator release of leukocytes and oxidative reactions of polymorphonuclear leukocytes.

This product is a first-generation cephalosporin, which has good antibacterial effect on some strains of Gram-positive cocci such as non-penicillinase-producing and penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococci, group A hemolytic streptococci, Streptococcus pneumoniae and viridans streptococci. Anaerobic Gram-positive bacteria are mostly sensitive to this product, and Bacteroides fragilis is resistant to this product. Methicillin-resistant Staphylococci and Enterococci are resistant to this product. The effect of this product on Gram-positive and Gram-negative bacteria is similar to that of cephalexin. This product has a certain effect on gonococci and is also active against enzyme-producing gonococci; its activity against Haemophilus influenzae is poor.

The antibacterial effect on Gram-positive cocci and bacilli (including anaerobic bacteria) is basically the same as that of penicillin, and the effect on Enterococcus faecalis is stronger than that of penicillin. Among Gram-negative bacteria, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella, Proteus mirabilis, Salmonella, etc. are all sensitive to this product. Some Escherichia coli and some Shigella are also sensitive to this product, but most Shigella are resistant to this product. Other Enterobacteriaceae, Pseudomonas aeruginosa, Bacteroides fragilis, etc. are resistant to this product. This product has a certain antibacterial effect on Legionella and Campylobacter fetus. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls, causing the bacteria to rupture and dissolve rapidly.

The antibacterial effect on Gram-positive cocci and bacilli (including anaerobic bacteria) is basically the same as that of penicillin, and the effect on Enterococcus faecalis is stronger than that of penicillin. Among Gram-negative bacteria, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella, Proteus mirabilis, and Salmonella are all sensitive to this product. Some Escherichia coli and some Shigella are also sensitive to this product, but most Shigella are resistant to this product. Other Enterobacteriaceae, Pseudomonas aeruginosa, Bacteroides fragilis, etc. are resistant to this product. This product has a certain antibacterial effect on Legionella and Campylobacter fetus.