Analgesic effect: by inhibiting the synthesis of prostaglandins and other substances; anti-inflammatory effect: may be by inhibiting the synthesis of prostaglandins or other substances that cause inflammatory reactions; antipyretic effect: may be by acting on the hypothalamic temperature regulation center to cause peripheral vasodilation, sweating and increased heat dissipation; anti-rheumatic effect: in addition to antipyretic and analgesic, it mainly has anti-inflammatory effects; inhibitory effect on platelet aggregation: by inhibiting platelet prostaglandin cyclooxygenase, thereby preventing the formation of thromboxane A2.

As a histamine H1 receptor antagonist, this product can counteract the capillary dilation caused by allergic reactions, reduce the permeability of capillaries, and relieve wheezing caused by bronchial smooth muscle contraction. This product has a long-lasting antihistamine effect and also has a significant central inhibitory effect, which can increase the effects of anesthetics, analgesics, hypnotics and local anesthetics. This product is mainly metabolized in the liver.

Selective calcium antagonists can block excessive calcium ions from entering cells across the membrane, preventing excessive intracellular calcium load. They can also prevent a large amount of calcium from entering neurons during ischemia and hypoxia, improve brain microcirculation and neuronal metabolism, inhibit cerebral vasospasm, platelet aggregation and increased blood viscosity, and also have a cell membrane stabilizing effect. This product is highly lipid-soluble and can easily pass through the blood-brain barrier. This product has no effect on cardiac contraction and conduction.

1. This product is a second-generation sulfonylurea antidiabetic drug, which is effective for most patients with type 2 diabetes. It can reduce fasting and postprandial blood sugar and reduce glycosylated hemoglobin (HbAlc) by 1% to 2%. 2. The main function of this type of drug is to stimulate pancreatic b cells to secrete insulin, but the prerequisite is that pancreatic b cells still have a certain function of synthesizing and secreting insulin. 3. Its mechanism is to specifically bind to the sulfonylurea receptor on the b cell membrane, thereby closing the K channel, causing changes in membrane potential, opening the Ca2 channel, and increasing intracellular Ca2, which promotes insulin secretion. 4. In addition, there are extra-pancreatic effects, including improving the insulin resistance of peripheral tissues (such as liver, muscle, and fat).

This product belongs to the class Ic (i.e., directly acting on the cell membrane) antiarrhythmic drug. The experimental results of isolated animal myocardium indicate that 0.5-1ug/min can reduce the depolarization effect during contraction, thereby prolonging conduction, slightly prolonging the duration of action potential and the effective refractory period, and can increase the threshold potential of myocardial cells, significantly reducing the spontaneous excitability of the myocardium. It acts on both the atrium and ventricle (mainly affecting the Purkinje fibers, with a smaller effect on the myocardium), and also on the formation and conduction of excitement. Clinical data show that the therapeutic dose (300mg orally and 30mg intravenously) can reduce the irritability of the myocardium, the effect is long-lasting, PQ and QRS are increased, and the effective refractory period of the atrium and atrioventricular node is prolonged. It has an antagonistic effect on various types of experimental arrhythmias.