In the carbon tetrachloride model, this product can reduce the serum transaminase and hydroxyproline content in the liver of animals, reduce the degree of liver lesions and reduce the level of DHBV-DNA in the serum of ducks infected with hepatitis B virus (HBV). In vitro tests show that this product can inhibit the proliferation of mouse skin fibroblasts (NIH/3T3 cells) and the synthesis of extracellular matrix; it can inhibit the proliferation of rat hepatic stellate cells and the synthesis of extracellular matrix, and promote their apoptosis. In the rat liver fibrosis model induced by carbon tetrachloride, dimethylnitrosamine and galactosamine, after oral administration of matrine for prevention and treatment, the serum transaminase, extracellular matrix (hyaluronic acid, laminin, type III collagen and type IV collagen) content of animals, as well as liver cell degeneration, necrosis, inflammatory activity and fibrosis in liver tissue were significantly improved.

It has a broad-spectrum antimicrobial effect, including aerobic Gram-negative and Gram-positive bacteria, anaerobes, Rickettsia, spirochetes and Chlamydia. It has a bactericidal effect on Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis, and only has an antibacterial effect on anaerobic bacteria such as Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Group B hemolytic Streptococcus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Salmonella paratyphi, Shigella, Bacteroides fragilis, etc. It is completely cross-resistant with chloramphenicol, has a high antibacterial activity in vivo, and has a strong immunosuppressive effect.

It has a broad spectrum of antimicrobial effects, including aerobic Gram-negative and Gram-positive bacteria, anaerobes, Rickettsia, spirochetes and Chlamydia. It has bactericidal effects on Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis, and only has antibacterial effects on anaerobic bacteria such as Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Group B hemolytic Streptococcus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Salmonella paratyphi, Shigella, Bacteroides fragilis, etc. Pseudomonas aeruginosa, Acinetobacter, Enterobacter, Serratia marcescens, indole-positive Proteus, methicillin-resistant Staphylococcus and Enterococcus are usually resistant to chloramphenicol. This product is an antibacterial agent that reversibly binds to the 50S subunit of the bacterial ribosome, inhibits protein synthesis, and is completely cross-resistant with chloramphenicol. It has a strong immunosuppressive effect, about 6 times stronger than chloramphenicol.