Nimodipine is a Ca2 channel blocker that inhibits smooth muscle contraction and relieves vasospasm by preventing Ca2 from entering cells. It has a strong effect on cerebral arteries, is lipophilic and easily penetrates the blood-brain barrier, and can be used to prevent vasospasm after subarachnoid hemorrhage. It also has the effect of protecting and promoting memory.

No specific pharmacological effects mentioned

It has an inhibitory effect on a variety of Gram-positive and Gram-negative bacteria in vitro, and has a stronger inhibitory effect on hemolytic Streptococcus, Staphylococcus aureus, Vibrio cholerae, Neisseria meningitidis, Shigella, Salmonella typhi, Corynebacterium diphtheriae, etc. It also has a certain inhibitory effect on amoeba.

It mainly interferes with bacterial folate metabolism, selectively inhibits dihydrofolate reductase, and prevents nucleic acid synthesis.

After entering the body, it can combine with poisons containing hydroxyl or carboxyl groups to form low-toxic or non-toxic compounds that are excreted in the urine, which has the effect of protecting the liver and detoxifying. In addition, glucuronic acid can increase the content of liver glycogen and reduce fat reserves.

After entering the body, glucuronide can combine with poisons containing hydroxyl or carboxyl groups to form low-toxic or non-toxic combinations that are excreted in the urine, which has the effect of protecting the liver and detoxifying. In addition, glucuronic acid can increase the glycogen content of the liver and reduce fat reserves. Vitamin B1 combines with adenosine triphosphate to form vitamin B1 pyrophosphate (thiamine triphosphate, cocarboxylase), which is a coenzyme necessary for carbohydrate metabolism; vitamin B1 can inhibit the activity of cholinesterase. When it is deficient, the activity of cholinesterase increases, the hydrolysis of acetylcholine is accelerated, and the conduction of nerve impulses is impaired, affecting gastrointestinal and myocardial functions. This product is mainly absorbed in the duodenum, metabolized in the liver, and excreted through the kidneys.

It combines with adenosine triphosphate to form vitamin B1 pyrophosphate (thiamine triphosphate, cocarboxylase), which is a coenzyme necessary for carbohydrate metabolism; it can inhibit the activity of cholinesterase. When it is deficient, the activity of cholinesterase increases, the hydrolysis of acetylcholine is accelerated, causing nerve impulse conduction disorders, and affecting gastrointestinal and myocardial function.

After oral absorption, this product slowly decomposes into formaldehyde and ammonia in acidic urine. Formaldehyde has a bactericidal effect. Ammonia can easily alkalinize urine, so it is necessary to take acidifying urine drugs such as ammonium chloride when taking it.