Guangxi Yuyuan Pharmaceutical Co., Ltd.

This product is an H2 receptor antagonist. It replaces the imidazole ring of cimetidine with a furan ring. It has a higher selectivity for H2 receptors and can significantly inhibit the basal and nocturnal gastric acid secretion of normal people and ulcer patients, as well as the gastric acid secretion caused by pentagastrin, histamine and meals. Its gastric acid inhibition effect is 5 to 12 times stronger than that of cimetidine. Intravenous injection of this product can reduce gastric acid secretion by 90%; it has a certain inhibitory effect on the secretion of pepsinogen. It has a protective effect on experimental gastric mucosal damage and acute ulcers. It has no effect on the secretion of gastrin and sex hormones.

Betahistine is a diamine oxidase inhibitor. It has a significant dilating effect on cerebrovascular and cardiovascular systems, especially on the conical artery system. It significantly increases the blood flow of the heart, brain and peripheral circulation, improves blood circulation, and lowers systemic blood pressure. In addition, it can increase the blood flow of the cochlea and vestibule, thereby eliminating inner ear vertigo, tinnitus and ear closure. It can also increase capillary permeability, promote the absorption of extracellular fluid, and eliminate lymphatic edema. It can counteract the vasoconstrictive effect of catecholamines and lower arterial pressure, and it has the effect of inhibiting blood coagulation and ADP-induced platelet aggregation, it can prolong the time of thrombosis in vitro in rats, and it also has a slight diuretic effect.

Antiviral effect

Directly relaxes smooth muscle, especially vascular smooth muscle; the dilation effect on post-capillary veins is more persistent than that on arteries. It has no obvious direct effect on the myocardium. Due to the dilation of capacitance vessels, the venous return to the heart is reduced, reducing the preload of the heart. At the same time, the peripheral resistance vessels expand, blood pressure drops, the left ventricular ejection resistance is reduced, and the afterload of the heart is reduced. The reduction of the preload and afterload of the heart reduces the oxygen consumption of the myocardium.