Unspecified

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It belongs to the 14-membered macrolide antibiotics. The antibacterial spectrum is the same as that of erythromycin and roxithromycin, but it is slightly better against Gram-positive bacteria such as Streptococcus, Pneumococcus, and Staphylococcus, and it also has certain antibacterial activity against induced erythromycin-resistant strains. Clarithromycin and its metabolites in the body enhance the antibacterial effect on influenza bacilli. It also has certain effects on gonococci, Listeria, and Campylobacter jejuni, and its effects on Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia trachomatis, and Ureaplasma urealyticum are stronger than erythromycin. It has a more prominent effect among the new varieties developed in recent years, with MIC90 of about 0.008-0.12 mg/L. In addition, it has certain activity against Borrelia burgdorferi, Mycobacterium avium, and Toxoplasma gondii, and most of them are better than other varieties. In addition to having a strong antibacterial effect on anaerobic cocci, its effect on Bacteroides fragilis is better than erythromycin. The antibiotic after-effect on Staphylococcus aureus, Streptococcus pyogenes, Haemophilus influenzae, etc. is significantly stronger than erythromycin. It inhibits the synthesis of protein by hindering the connection of the 50S subunit of the nucleoprotein. It has an inhibitory effect on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus, Pneumococcus, etc., and also has an inhibitory effect on some Gram-negative bacteria such as Haemophilus influenzae, Bordetella pertussis, Gonorrhea, Legionella pneumophila and some anaerobic bacteria such as Bacteroides fragilis, Streptococcus, Propionibacterium acnes, etc. In addition, it also has an inhibitory effect on mycoplasma. The characteristics are that the antibacterial activity in vitro is similar to that of erythromycin, but the antibacterial activity in vivo against some bacteria such as Staphylococcus aureus, Streptococcus, Haemophilus influenzae, etc. is stronger than erythromycin. There is cross-resistance between it and erythromycin.