Zhejiang Yongning Pharmaceutical Co., Ltd.

This product is a second-generation cephalosporin antibiotic. It is rapidly hydrolyzed into cefadroxil after entering the body. It has a strong antibacterial effect on most Gram-positive cocci, has a good effect on diphtheria and Gram-positive anaerobic bacteria, has strong activity against Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae and Haemophilus influenzae, and is sensitive to some Enterobacter aerogenes, indole-positive Proteus and Providencia. It is also very sensitive to Salmonella typhi, Shigella, Neisseria gonorrhoeae and Neisseria meningitidis. It has a poor effect on Bacteroides fragilis, and is resistant to Serratia, Alcaligenes, Acinetobacter and Pseudomonas aeruginosa. Its mechanism of action is to bind to penicillin-binding proteins (PBPs) on the bacterial cell membrane, inhibit the synthesis of bacterial septa and cell walls, make the bacteria longer in shape, and finally dissolve and die.

This product is a second-generation cephalosporin antibiotic. Cefuroxime sodium is rapidly hydrolyzed into cefadroxil after entering the body, and the antibacterial effects of the two in the body are basically the same. Cefuroxime has a strong antibacterial effect on most Gram-positive cocci, and its activity is similar to that of cephalothin and cefazolin. Enterococci and methicillin-resistant Staphylococcus aureus are resistant to this product. This product has a good effect on diphtheria Corynebacterium and Gram-positive anaerobic bacteria (anaerobic cocci and Clostridium), and its activity against Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae and Haemophilus influenzae is stronger than that of cephalothin and cefazolin. Some aerogenes Enterobacter, indole-positive Proteus and Providencia are sensitive to this product. Salmonella typhi, Shigella, Neisseria gonorrhoeae and Neisseria meningitidis are also very sensitive to this product, and its antibacterial effect on Bacteroides fragilis is poor. Serratia, Alcaligenes, Acinetobacter and Pseudomonas aeruginosa are resistant to this drug. Its mechanism of action is to bind to penicillin-binding proteins (PBPs) on the bacterial cell membrane, acylate transpeptidase, inhibit the synthesis of bacterial septa and cell walls, affect the cross-linking of cell wall mucopeptide components, inhibit cell division and growth, elongate the bacterial morphology, and finally dissolve and die.

It achieves bactericidal effect by inhibiting biosynthesis of sensitive bacterial cell walls. When used in combination with sulbactam, it has obvious synergistic effect.

It has an irreversible inhibitory effect on most important β-lactamases produced by β-lactam antibiotic-resistant strains, protecting β-lactam antibiotics from hydrolysis and destruction by β-lactamases of resistant bacteria. It can combine with certain penicillin-binding proteins to enhance its effect on sensitive strains.

The second-generation cephalosporin antibiotics have similar or slightly inferior antibacterial activity against Gram-positive cocci as the first-generation cephalosporins, but are quite stable against beta-lactamase produced by Staphylococci and Gram-negative bacilli. Methicillin-resistant Staphylococci, Enterococci and Listeria are resistant, and other positive cocci (including anaerobic cocci) are sensitive to this product. The antibacterial activity against Staphylococcus aureus is worse than that of cefazolin, and 1-2 mg/L can inhibit all Staphylococcus aureus that are sensitive and resistant to penicillin, respectively. It has strong antibacterial activity against Haemophilus influenzae, and Escherichia coli, Proteus mirabilis, etc. may be sensitive to this product; indole-positive Proteus, Citrobacter and Acinetobacter have poor sensitivity to this product, most Serratia are resistant, and Pseudomonas aeruginosa, Campylobacter and Bacteroides fragilis are resistant to this product. Its mechanism of action is to bind to penicillin-binding proteins (PBPs) on the bacterial cell membrane, acylate the transpeptidase, inhibit the synthesis of the bacterial septum and cell wall, affect the cross-linking of the cell wall mucopeptide components, inhibit cell division and growth, elongate the bacterial morphology, and finally dissolve and die.

The second-generation cephalosporin antibiotics have similar or slightly worse antibacterial activity against Gram-positive cocci than the first-generation cephalosporins, but are quite stable against β-lactamase produced by Staphylococci and Gram-negative bacilli. Methicillin-resistant Staphylococci, Enterococci and Listeria are resistant, and other positive cocci (including anaerobic cocci) are sensitive to this product. The antibacterial activity against Staphylococcus aureus is worse than that of cefazolin, and 1-2 mg/L can inhibit all Staphylococcus aureus that are sensitive and resistant to penicillin, respectively. It has strong antibacterial activity against Haemophilus influenzae, and Escherichia coli, Proteus mirabilis, etc. may be sensitive to this product; indole-positive Proteus, Citrobacter and Acinetobacter have poor sensitivity to this product, most Serratia are resistant, Pseudomonas aeruginosa, Campylobacter and Bacteroides fragilis are resistant to this product. Its mechanism of action is to bind to penicillin-binding proteins (PBPs) on the bacterial cell membrane, acylate the transpeptidase, inhibit the synthesis of the bacterial septum and cell wall, affect the cross-linking of the cell wall mucopeptide components, inhibit cell division and growth, elongate the bacterial morphology, and finally dissolve and die.